Vrije PhD position in Molecular Neuroscience, Biochemistry, Genetics

Vrije Universiteit Amsterdam (VU)

The Netherlands

Center for Neurogenomics and Cognitive Research (CNCR) invites applications for a PhD position to work in an ambitious research environment, at Vrije Universiteit Amsterdam, the Netherlands

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General Info

Position: PhD position
No. of Positions: 1
Research Field: , ,
Deadline to Apply: Expired
Joining Date: ASAP
Contract Period: 1 Year
Salary: 2,395 to 3,061 Euro/Month

Center for Neurogenomics and Cognitive Research (CNCR)
Vrije Universiteit Amsterdam
Vrije Universiteit Amsterdam (VU)

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Qualification Details

  • MSc in any of the of the following fields: Molecular Neuroscience, Biochemistry or Neuroscience and Genetics
  • experience with molecular techniques, preferably proteomics; bioinformatics; computational biology
  • a good ability to write and read English
  • experience with Python, or R language and some experience with scientific programming
  • support ‘open science’: share tools and data with the wider scientific community

Responsibilities/Job Description

  • perform mass-spectrometry based proteomics analysis of the human postmortem brain
  • apply bioinformatic tools for integrating results from different biological resources
  • actively take part in discussions and have frequent contact with CNCR genetics and neuroscience labs
  • authoring and co-authoring manuscripts submitted to high quality journals
  • support (10% of time) with teaching
  • frequently present work at international communities (at conference calls, or conferences)

How to Apply?

Online Application through "Apply Now" Button from this page or from advertisement webpage (URL below)

Reference Number: -
(If any, use it in the necessary place)

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Documents Required

You are requested to write a letter in which you describe your abilities and motivation, accompanied by your curriculum vitae, a list of grades of your MSc and the names and contact details of two scientific referees. Please compile all this together in one document and convert it to pdf.

About the Project

The Complex Trait Genetics (ctg.cncr.nl) and the Molecular and Cellular Neuroscience labs (mcn.cncr.nl) labs at the Center for Neurogenomics and Cognitive Research in Amsterdam (see www.cncr.nl) are seeking applicants for a PhD position in proteomics analysis of the human brain. The successful candidate will be part of an ERC project from the department of Complex Trait Genetics. The main aim of the project is to gain insight into the individual diversity of the human brain proteome, and the integration of this data with recent genetic and genomic discoveries, utilizing large-scale bioinformatic resources.

Various types of -omics analyses have shed light on the molecular architecture of the human brain. Single cell transcriptome analysis has advanced our knowledge on cell types and gene expression in the brain. New technologies in high-throughput proteomics analysis now allow to generate a comprehensive high-resolution description of protein expression of the human brain. The work of the candidate will focus on generating high resolution protein expression data of the human brain and applying existing analytical tools that integrate this data with other resources (e.g. scRNAseq, bulk mRNA, chromatin interaction data) and with results from genetic discovery studies for brain related disorders. Particular attention will be given to differences in molecular signatures between individuals and how this diversity relates to individual genetic make-up.  Also, the role of alternative splicing in generating protein diversity in different areas of the brain will be studied. Interpretation of these results in neurobiological and genetic context will be a very important part of the work. The candidate will work in an enthusiastic team of PhD students and postdocs, with diverse backgrounds, including, bioinformatics, artificial intelligence, experimental neuroscience, psychology and stem cell biology.

You need to have experience with molecular neuroscience; ideally you have experience with proteomics analysis. You have affinity with working with large datasets and have knowledge of R, or other scientific coding/programming. Affinity with genetics is also preferred.

About the Employer: Vrije Universiteit Amsterdam (VU)

Note or Other details

What we offer

A challenging position in a socially involved organization. The salary will be in accordance with university regulations for academic personnel and amounts €2,395 (PhD) per month during the first year and increases to €3,061 (PhD) per month during the fourth year, based on a full-time employment. The job profile: Promovendus (PhD) is based on the university job ranking system and is vacant for 1 FTE.The appointment will initially be for 1 year. After a satisfactory evaluation of the initial appointment, the contract will be extended for a total duration of 4 years. Additionally, Vrije Universiteit Amsterdam offers excellent fringe benefits and various schemes and regulations to promote a good work/life balance, such as:

  • a maximum of 41 days of annual leave based on full-time employment
  • 8% holiday allowance and 8.3% end-of-year bonus
  • solid pension scheme (ABP), contribution to commuting expenses

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Contact details

Name: prof. dr. Danielle Posthuma
Position: Head of the Complex Trait Genetics lab
E-mail: danielle.posthuma@vu.nl Telephone: + 31 20 598 28 23

Name: prof. dr. Guus Smit
Position: Head of the Molecular and Cellular Neurobiology lab
E-mail: guus.smit@vu.nl


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