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UCPH PhD Fellowship – Mammalian Developmental Epigenetics, Molecular Medicine

University of Copenhagen (UCPH)

Denmark

UCPH invites applications for PhD fellowship to study epigenetic and transcriptional dynamics in early mammalian embryos and pluripotent stem cells commencing at the Developmental Epigenetics & Disease Lab (Messerschmidt Laboratory), The Department of Cellular and Molecular Medicine (ICMM), Denmark – Oct 2021

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General Info

Position: PhD Fellow
No. of Positions: 1
Research Field: , , ,
Deadline to Apply: Expired
Joining Date: Jan 01, 2021 
Contract Period: 3 Years
Salary: 27,871 DKK/Month

Workplace:
Developmental Epigenetics & Disease Lab
Department of Cellular and Molecular Medicine
University of Copenhagen (UCPH)
Copenhagen K,

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Qualification Details

Applicants must have qualifications corresponding to a master’s degree related to the subject area of the project.

Other important criteria are:

  • The grade point average achieved
  • Professional qualifications relevant to the PhD project
  • Previous publications of research projects
  • Relevant work experience
  • Other professional activities
  • Curious mind-set with a strong interest in Developmental and Molecular Biology as well as Epigenetics
  • Excellent English skills both written and spoken

Responsibilities/Job Description

Your key tasks as a PhD student at SUND are:

  • Carry through an independent research project under supervision
  • Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points
  • Participate in active research environments including a stay at another research team
  • Obtain experience with teaching or other types of dissemination related to your PhD project
  • Teach and disseminate your knowledge
  • Write a PhD thesis on the grounds of your project.

How to Apply?

Online Application through "Apply Now" Button from this page

Reference Number: -
(If any, use it in the necessary place)

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Documents Required

Your application must be submitted electronically by clicking ‘Apply now’ below. The application must include the following documents in PDF format:

  1. Motivated letter of application (max. one page)
  2. CV incl. education, experience, language skills and other skills relevant for the position
  3. Master of Science diploma and transcript of records. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor will do
  4. Publication list (if available)

Application deadline: October 6, 2021, 23.59 p.m. CET.

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process: After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor.

The assessor makes a non-prioritized assessment of the academic qualifications and experience with respect to the above-mentioned area of research, techniques, skills and other requirements listed in the advertisement.

Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/.

About the Project

Mammalian development is not merely defined by the information encoded in our DNA, but also by how this information is interpreted. This is achieved by chemical modifications (epigenetic modifications), allowing or restricting access to the genetic information without altering the DNA code itself.  Defects in this epigenome can be equally damaging to health and development as mutations to the DNA itself.

For successful reproduction, the genome of the newly formed embryo must be stripped of most epigenetic information. Yet, an unknown portion of the parental epigenome is transmitted with the genetic material at fertilization and fulfils important roles in the embryonic development and homeostasis of the progeny. Revealing this heritable epigenetic information, its functional relevance and the machineries involved in the transmission in humans and mice is the essence of our research in the laboratory.

The epigenetic regulator TRIM28, targeted to DNA by KRAB-Zinc finger proteins, is central to this process. We have shown that loss of maternal TRIM28 causes profound epigenetic defects and to date identified several instances of disrupted epigenetic inheritance in this model (see our published work). Our findings suggest the TRIM28-complex plays a central role in epigenetic inheritance and targets and functions go far beyond our current understanding. The successful candidate will build on this foundation and work to enhance our understanding of TRIM28-mediated inheritance, expand beyond it and most centrally, address germline-to-soma inheritance.

Principal supervisor is Associate Professor Daniel M. Messerschmidt, Department of Cellular and Molecular Medicine (ICMM), Faculty of Health and Medical Sciences, University of Copenhagen. Contact: E-mail: danielm@sund.ku.dk or phone: +45 3532 0286.

About the Group and Research

We research epigenetic and transcriptional dynamics in mammalian embryos during oocyte-to-embryo transition and beyond. We study transcription factors and epigenetic modifiers and their roles in epigenetic programming, re-programming and stability at early developmental stages. We seek to uncover novel epigenetic features inherited or established at these early stages impacting on later development, adult homeostasis and/or disease.

For more details, please visit developmental-epigenetics.com, see previous publications or feel free to contact Associate Professor Daniel M. Messerschmidt, e-mail: danielm@sund.ku.dk.

About Department of Cellular and Molecular Medicine

The place of employment is at the Department of Cellular and Molecular Medicine (ICMM), University of Copenhagen. ICMM offers a creative and ambitious scientific environment, with many different nationalities represented. ICMM aims to produce research with high international impact focusing on the functional cell, its genetic components and molecular cellular mechanisms in a medical context. ICMM currently comprises five research programs, three high profile Research Centers as well as a number of international research groups. The scientists at ICMM are involved in high quality research based undergraduate and graduate teaching programs at the University of Copenhagen.

More information can be found at https://icmm.ku.dk/english/.

About the Employer: University of Copenhagen (UCPH)

Terms of employment

The employment as PhD fellow is full time (37 working hours per week in average) and for 3 years.

It is conditioned upon the applicant’s successful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project formulated by the applicant.

The PhD study must be completed in accordance with The Ministerial Order on the PhD programme (2013) and the Faculty’s rules on achieving the degree. Salary, pension and terms of employment are in accordance with the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins at DKK 27,871 / approx. EUR 3,747 (October 2021-level) plus pension.

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Contact details

For specific information about the PhD fellowship, please contact the principal supervisor (see above).

General information about PhD study at the Faculty of Health and Medical Sciences is available at the Graduate School’s website: https://healthsciences.ku.dk/phd/guidelines/.

Advertisement Details: PhD fellowship in Mammalian Developmental Epigenetics at the Department of Cellular and Molecular Medicine (ICMM)

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