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Technician Job on development of immunotherapy for cancer – Maastricht, Netherlands 2022

Maastricht University (UM), The Netherlands

Faculty of Health, Medicine and Life Sciences recruits Technician on development of immunotherapy for cancer at School GROW, Department of Internal Medicine – Maastricht University, Netherlands 2022

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General Info

Position: Technician
No. of Positions: 1
Research Field: ,
Joining Date: ASAP
Contract Period: 3 years
Salary: € 3.196/month

Workplace:
Faculty of Health, Medicine and Life Sciences, School GROW
Department of Internal Medicine
Maastricht University (UM)
Maastricht, The Netherlands

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Qualification Details

we are looking for a motivated technician who will closely work together with the PhD candidate. You should have:

  • A BSc degree (or equivalent) in a relevant Life Science discipline from a university of Applied Sciences;
  • Experience with molecular biology is required;
  • Previous experience cell culture is an advantage;
  • Excellent communication skills in English.

Responsibilities/Job Description

We are recruiting a PhD student and a technician to develop chimeric antigen receptor (CAR) natural killer (NK) cells and to study their application in breast cancer.

NK cells are effector cells of our immune system that can kill malignant cells. We have demonstrated clinical efficacy of NK cells, both in models for M. Myeloma and breast cancer. In a consortium we will further explore the role of NK cells in metastatic (lobular) breast cancer, bringing groups together to combine knowledge on NK cells and preclinical breast cancer models. The anti-tumor effect of NK cells will be studied in mouse (PDX) models and human patient-derived tumor organoid (PDO) models. In the project, we will develop second generation NK cells, like Chimeric Antigen Receptor (CAR)-NK cells or siRNA inhibition of these cells, to optimize NK cell effectivity. The PDX and PDO models are expected to be predictive for clinical effects of NK and CAR-NK cells.

The successful applicants will work under the supervision of Prof. dr Gerard Bos (Faculty of Health, Medicine and Life Sciences and CEO of CiMaas BV)), Dr. Wilfred Germeraad (Faculty of Health, Medicine and Life Sciences and CSO of CiMaas BV), Dr Lotte Wieten (Maastricht University Medical Center+) in collaboration with Prof dr. Patrick Derksen (Utrecht University Medical Center), on a translational project using new DNA constructs, virus production, in vitro cell culture, animal models and GMP production of clinical grade (CAR)-NK cells.

How to Apply?

Online Application through "Apply Now" Button from this page


Reference Number: AT2021.472
(If any, use it in the necessary place)

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Documents Required

The application should include:

  • Curriculum Vitae (CV)
  • Motivation letter
  • Diplomas/degrees including a grade transcript of previous education at Master level and/or bachelor level
  • Willingness to provide two letters of academic reference, assessing the applicant’s research potential and personality, should be sent independently by the referees
  • Proof of academic writing skills by one of the following: BSc thesis, MSc thesis, or research paper.

You can respond to this vacancy to: hrm-rw-vacatures@maastrichtuniversity.nl.

Mention also the vacancy number/job number (AT2021.472) and the project name in your application.

About the Department of Internal Medicine

The scientific research of the department of Internal Medicine combines basic science with translational and clinical research. Our research group has strong links with clinical departments within the Maastricht UMC+ as well as many (inter)national collaborations with academic and industrial partners. CiMaas BV is a spinoff from the department and founded in 2015 by Gerard Bos and Wilfred Germeraad and is currently located on the Brightlands Chemelot Campus where it operates research and GMP manufacturing laboratoria.

Within this project, the candidate will collaborate with the department of Pathology from the UMC Utrecht to perform organoid cultures and animal models with (CAR)-NK generated NK cells.

About the Employer: Maastricht University (UM)

Note or Other details

Fixed-term contract: 3 years.

The position is temporary for the duration of 3 year. Depending on experience and qualification, the maximum gross monthly salary is € 3.196,- (on a full-time basis) in accordance with scale 7 of the Dutch university collective bargaining agreement. An 8% holiday and an 8.3% year-end allowance is also provided.

The terms of employment of Maastricht University are set out in the Collective Labour Agreement of Dutch Universities (CAO). Furthermore, local UM provisions also apply.


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Contact details

For questions about this position please contact: Prof. Dr. Gerard Bos, email gerard.bos@mumc.nl

Advertisement Details: Technician on development of immunotherapy for cancer, Faculty of Health, Medicine and Life Sciences, School GROW - Department of Internal Medicine

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