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Research Engineer in NMR-Based Structural Biology at Gothenburg University, Sweden, 2022

Sweden, University of Gothenburg

Department of chemistry and molecular biology invites applications for a Research Engineer in NMR-Based Structural Biology, at University of Gothenburg, Sweden, 2022

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General Info

Position: Research Engineer
No. of Positions: 1
Research Field: , , ,
Joining Date: ASAP
Contract Period: -
Salary: According to Standard Norms

The group of Björn Burmann
Department of chemistry and molecular biology
University of Gothenburg
Gothenburg , Sweden

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Qualification Details

An advanced degree in a relevant field such as Molecular Biology, Biochemistry, Biophysics, Structural Biology or related fields is expected. Previous work on related protein systems will be considered favorable. The successful candidate should have a strong background in biochemistry, biophysics, and NMR spectroscopy. Previous work related to serine proteases, e.g. expression and purification and/or functional characterization for structural studies, will be considered an advantage. Possessing detailed experience in the following techniques is considered mandatory:

  • Knowledge in recombinant protein expression and purification of relevant proteins, such as bacterial DegP or DegQ.
  • Expert knowledge in solution NMR methods (e.g. assignment, protein dynamics, data analysis)
  • Expert knowledge in sample preparation (isotope labelling, methyl-labelling)
  • Detailed knowledge in additional biophysical and structural biology techniques (ITC, BLI, SEC-MALLS, EM, X-Ray)
  • Documented knowledge in automated data procession and analysis

Furthermore, a genuine interest in structure and dynamics or protein function is required. Co-Authorship in high impact journals such as Nature, Science or Science Advances is considered favorable.

Responsibilities/Job Description

The research project aims at advancing the molecular understanding of the function and regulation of bacterial homo-oligomeric serine proteases by advanced NMR-spectroscopy. Malfunction of these fundamental proteases leads to the accumulation of misfolded proteins and thus provide the foundation for cell death in bacteria. Specifically, you will study (1) the molecular mechanisms by which the bacterial DegP protease is regulated and activated (2) how it recognizes and subsequently cleaves misfolded protein substrates, and (3) how the DegP is regulated by and interacting with auxiliary factors. To achieve this goal, you will use a plethora of techniques ranging from basic biochemistry to advanced structural biology methods and biophysical characterization. Methods in microbiology, molecular biology, bioinformatics and biochemistry will also be used. We are looking for a colleague, that is highly motivated, scientifically independent, and creative, and capable of contributing to a team environment.

How to Apply?

Application Method: Online Application
Ref. No.: PAR 2021/1695

Application Procedure

The application shall include:

Cover letter with an explanation of why you apply for the position

CV including scientific publications

Copy of exam certificate

Two referees (name, telephone no, relation)

About the Project/Department

Research and graduate education at the department of chemistry and molecular biology comprises a wide scientific field from the atomic and molecular levels all the way through cells to intact organisms. Much of the phenomena studied here impact on our natural environment and living systems. We participate in undergraduate programs in chemistry, molecular biology, medicinal chemistry, biology, marine sciences, and pharmacy.

The group of Björn Burmann uses state of the art NMR-spectroscopy to study large molecular complexes underlying basic cellular functions at the atomic level in combination with other structural biology methods and biophysical characterization. Björn Burmann’s group investigates macromolecular protein machines underlying essential cellular functions, e.g. protein quality control and their effect on misfolding- and aggregation-prone proteins underlying several different diseases, through biophysical and structural biology approaches e.g. high-resolution Nuclear Magnetic Resonance (NMR). Results of previous studies into molecular chaperones and functional mechanism of proteases at the atomic level have been published in top journals. More details on our research can be found at: Structural characterization and biophysical analysis of transcription associated processes.

About the Employer: University of Gothenburg

Note or Other details

The employment is a fixed term during 6 months, fulltime at the Department of Chemistry and Molecular Biology


Union representatives at the University of Gothenburg:

Information for International Applicants

Choosing a career in a foreign country is a big step. Thus, to give you a general idea of what we and Gothenburg have to offer in terms of benefits and life in general for you and your family/spouse/partner please visit:

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Contact details

Regarding the position, please contact Björn Burmann, Associate Professor, +46(0)31 786 3923

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