Research assistant – Karolinska Institutet, Sweden, 2022

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Two Research Assistant positions in 3D Genomics are immediately available in the Bienko and Crosetto lab for Quantitative Genome Biology at the Science for Life Laboratory (SciLifeLab), at Karolinska Institutet, Sweden, 2022

Qualification Details

Do you like to work at the bench and make experiments? Do you want to develop knowledge and skills in the exciting field of 3D genome biology? Are you meticulous, attentive to detail, analytical, and self-critical? Then you are the right person! If you have previously worked with NGS techniques, that’s great! However, we also welcome applications from people without prior experience in NGS who have a demonstrated track record of working with molecular biology and protein biochemistry techniques. To be eligible for this position, you must have obtained a bachelor and/or master’s degree in biology, biotechnology, bioengineering, medicine, biomedicine or equivalent not more than two years before the deadline of this application.

Responsibilities/Job Description

As a Research Assistant in our lab, you will be trained in a variety of methods for studying the 3D genome architecture, including the GPSeq method that we previously developed for profiling the radial placement of the genome in the nucleus (Girelli et al, Nat Biotech 2020) and the Hi-C method for probing chromosome contacts genome-wide (Lieberman-Aiden et al, Science 2009). You will then contribute to various ongoing projects in our lab by applying these methods to different cell model systems and working alongside postdocs and PhD students in our group to analyze and interpret the resulting data. You will be embedded in an international and culturally diverse thriving research environment, surrounded by senior scientists, postdocs and PhD students from very different backgrounds, giving you the opportunity to learn new concepts, developing your experimental skills, and fostering your creativity. Your primary task will be supporting other experimentalists in the lab, by performing GPSeq, Hi-C and other 3D genome mapping methods in the context of various ongoing projects. Specific tasks include:

  • Culturing cells and preparing samples for GPSeq and Hi-C
  • Performing our YFISH fluorescence in situ hybridization (FISH) assay to monitor the gradual radial chromatin digestion in the GPSeq protocol
  • Performing the full GPSeq and Hi-C protocols, including library quality check and sequencing on our NextSeq 2000 machine
  • Participating to the interpretation and analysis of the sequencing results together with postdocs/PhD students in our group.

How to Apply?

Application Method: online_applicationRef. No. STÖD 2-3902/2022

Application Procedure

The application is to be submitted through the Varbi recruitment system.In this recruitment, you will apply with your CV without a personal letter. Instead, you will answer some questions about why you are applying for the job in the application form.

About the Department/Section/Group

Our lab focuses on developing and applying cutting-edge experimental and computational methods to investigate the three-dimensional (3D) organization of the genome in the nucleus of mammalian cells and how this influences gene expression regulation and cell identity.

Note or Other details

A creative and inspiring environment with wide-ranging expertise and interests. Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote a better health for all. At Karolinska Institutet, we conduct successful medical research and hold the largest range of medical education in Sweden. Karolinska Institutet is also a state university, which entitles you to several good benefits through our collective agreement. And you get to practice freely in our modern wellness facilities, where trained staff are on site.

Contact Details

Magda Bienko, [email protected]