Postdoctoral Researcher in structural biochemistry of mitochondrial RNA biogenesis

Karolinska Institute (KI)

Sweden

Karolinska Institutet invites applications for a postdoctoral fellow who are interested in studying the structural cell biology of mitochondrial genome separation and segregation to join the Hällberg laboratory, Department of Cell and Molecular Biology, Stockholm, Sweden – Oct 2021

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General Info

Position: Postdoctoral Fellow
No. of Positions: 1
Research Field: , ,
Deadline to Apply: Expired
Joining Date: ASAP
Contract Period: Not Mentioned
Salary: According to Standard Norms

Workplace:
Hällberg laboratory
Department of Cell and Molecular Biology
Karolinska Institute (KI)
Solna,

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Qualification Details

Qualified to be employed as a postdoctor is one who has obtained a doctorate or has equivalent scientific competence. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) date of employment. This must be substantiated by the applicant's main supervisor, director or equivalent.

We are looking for highly motivated, independent and driven candidates. The successful applicant will have extensive experience with structural determination of mitochondrial protein degradation proteins and mitoribosome assembly intermediates. Furthermore, experience of RNA/RNA-protein structural biochemistry is a further advantage. A documented ability and more than 1-year experience in independent operation of a 300 kV Krios microscope and cryo-FIB-SEM is required for this position. Furthermore, a documented ability to independently carry out experimental research projects is required, as are good communication skills in spoken and written English.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Responsibilities/Job Description

The project is part of a multi-disciplinary collaboration – financed by the Knut and Alice Wallenberg Foundation – between the groups of Alexey Amunts at Stockholm University and the groups of Joanna Rorbach and Martin Hällberg at the Karolinska Institutet.

Duties

The project aims to structurally and biochemically characterize the ribosomal maturation process. The Hällberg subproject in the collaboration focuses on the very earliest mito-rRNA maturation steps that occur co-transcriptionally and involves the early processing steps and their coordination with binding of ribosomal proteins and maturation factors. Main techniques involved are electron microscopy (cryo-EM), macromolecular crystallography and biochemistry. We have ample access to Karolinska Institutet’s 3D-EM facility that currently features a Krios G3i with a Bioquantum K3, an Aquilos2 cryo-FIB-SEM, a Leica SP8 cryo-confocal, a Talos 120C G2 and a range of sample-preparation equipment.

How to Apply?

Online Application through "Apply Now" Button from this page or from advertisement webpage (URL below)

Reference Number: STÖD 2-4191/2021
(If any, use it in the necessary place)

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Documents Required

An employment application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and a summary of skills and experience
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted through the Varbi recruitment system.

Applications will be screened continuously, and we may start the interview process before the last day of application.

About Martin Hällberg's Group

Structural basis of RNA biogenesis

The Hällberg group investigates molecular mechanisms of mitochondrial and viral gene expression. For mitochondrial gene expression we are working on the aspects of early RNA processing, mitoribosome biogenesis and genome segregation. For viral replication we are primarily interested in the Herpesviral replication machinery as a target for better antiviral therapies.

During the Covid-19 pandemic the group has collaborated to help develop therapeutic interventions towards active viral infection, primarily using nanobodies against the SARS-CoV-2 spike protein.

We are using an integrative structural cell biology approach using a combination of cryoelectron tomography, single-particle cryo-electron microscopy, cryoconfocal microscopy, biochemistry, X-ray crystallography and small-angle-X-ray scattering.

About the Employer: Karolinska Institute (KI)

Offer

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

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Contact details

  • Martin Hällberg, martin.hallberg@ki.se

Union representative

  • Magnus Anå, OFR, 08-524 864 37, magnus.ana@ki.se
  • Taher Darreh-Shori, SACO, 08-524 835 29
  • Elisabeth Valenzuela, SEKO, 08-524 863 53

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