The Department of Chemistry at Umeå University are offering a postdoctoral fellowship in medicinal chemistry within the team that focus on the impact of fibroblasts on the development of pancreatic cancer.
Position: Postdoctoral fellowship
No. of Positions: 1
Research Field: Medicinal Chemistry, Organic Chemistry
Deadline to Apply: August 9, 2021 (GMT +2)
Joining Date: ASAP
Contract Period: 2 Years
Salary: According to Standard Norms
A person who has been awarded a doctorate or a foreign qualification deemed to be the equivalent, in organic chemistry, or in another relevant field. Priority should be given to candidates who have completed their doctoral degree no more than three years before the closing date of the application. A candidate who has completed their degree prior to this may be considered if special circumstances exist. Special circumstances include absence due to illness, parental leave or clinical practice, appointments of trust in trade unions or similar circumstances. Special circumstances should be clearly stated in the application.
Previous experience in bioorganic synthesis including purification/characterization techniques such as HPLC, NMR, and MS is a requirement. The successful candidate is expected to drive his or her studies forward independently as well as in collaboration with other members of the team, independence and good ability to collaborate are therefore requirements. Good command of written and spoken English is also a requirement. Previous experience of analyzing pharmacokinetic data and computational software (e.g. the Molecular Operative Environment (MOE)) and methods for pharmacophore studies and pharmacokinetic predictions is meriting.
Pancreatic cancer has a very high mortality rate and currently no effective treatment options are available. A unique feature of the disease is the pronounced fibrotic stroma that surrounds tumour cells. This tumour stroma consists of an extracellular matrix (ECM), fibroblasts, which together provide the cancer cells with important signals that regulate tumour growth. This makes the stroma an interesting target from a treatment perspective, but the lack of knowledge in the complexity of the stroma has hampered the development of drugs targeting stromal interactions.
We are now offering a postdoctoral fellowship in medicinal chemistry within the team that focus on the impact of fibroblasts on the development of pancreatic cancer. The postdoctoral fellowship focus on design and synthesis of heterocyclic compounds to e.g. optimize compound potency and properties, achieve structure-activity relationships, and for mode of action studies. The research project is highly interdisciplinary with established collaborations to effectively evaluate and explore generated compounds in animal models, human tissues, and organoid-based co-culture systems. The overall aim with research project is to identify and explore critical interactions between pancreatic cancer cells and fibroblasts, and to develop new therapeutic strategies that target the disease by selectively blocking or stimulating these interactions.
How to Apply?
Send email through "Apply Now" Button from this page or from advertisement webpage (URL below)Reference Number: FS 2.1.6-1226-21
(If any, use it in the necessary place)
- Candidates should submit:
- Cover letter including research interests and qualifications (maximum 1 page),
- Curriculum vitae (CV) including list of technical expertise and list of publications,
- Certified copies of diplomas and link to PhD thesis.
- Names and contact details of two reference persons
- Other documents you wish to claim
Submit your application as a PDF marked with the reference number FS 2.1.6-1226-21, both in the file name and in the subject field of the email, to firstname.lastname@example.org. The application can be written in English (preferably) or Swedish.
About the Department
The Department of Chemistry is the largest department within the Faculty of Science and Technology with approximately 200 employees and a strong and expanding research. The department is located within the Chemical Biological Centre (www.kbc.umu.se) at Umeå University and provides excellent facilities and state-of-art equipment and platforms in a creative, inspiring, international and highly interactive environment. For more information, see: www.umu.se/en/department-of-chemistry/.
About the Employer: Umeå University (UMU)
For more information, please contact associate professor Erik Chorell, Department of Chemistry, at email@example.com.
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