Postdoc jobs or Researcher in Position UCPH University of Copenhagen, Denmark

Postdoc position – Structural biology, Biophysics, Biochemistry – UCPH, Denmark, 2022

Denmark

The Autzen Lab at the Department of Biology invites applications for a postdoc position in membrane protein biochemistry and structural biology at University of Copenhagen, Denmark – 2022

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General Info

Position: Postdoc position
No. of Positions: 1
Research Field: , ,
Deadline to Apply: Expired
Joining Date: Aug 01, 2022
Contract Period: 2 Years
Salary: According to standard norms

Workplace:
Autzen Lab at the Department of Biology

University of Copenhagen (UCPH), Denmark

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Qualification Details

Experience within membrane protein structural biology is an advantage, but not a requirement. The formal requirements of the successful applicant are:

  • A PhD in structural biology, biophysics or biochemistry.
  • An excellent scientific track record, including a first-author publication within the field of structural biology, biophysics or biochemistry.
  • Experience working with bacterial and/or mammalian tissue culture
  • Experience with protein expression and purification.
  • Experience with recombinant DNA techniques and cloning.
  • Experience in data management and reporting.
  • Demonstrated ability to quickly grasp and employ new methods and tools.
  • An ability to work independently and thrive working as part of a team.
  • Proficiency in spoken and written English, with good interpersonal communication skills.
  • High level of motivation, responsibility, and ability to work in a structured manner.

As criteria for the assessment of your qualifications, emphasis will be laid on publications and relevant research experience and references. In addition to the formal requirements above, we are looking for a candidate that has experience within or strong qualifications for the following areas:

  • Membrane protein expression and purification.
  • Membrane protein-ligand binding assays.
  • Cryo-EM, X-ray crystallography and/or NMR.
  • Cryo-EM data processing and/or protein modelling.
  • Working with Linux operating systems.
  • Basic programming (MatLab and/or Python).

Responsibilities/Job Description

This project aims at advancing our understanding of the molecular mechanisms underlying pH regulation in the endosomal trafficking system by exploring the structure and function of Na+/H+ exchangers.

The specific aim of the project is to study the structure, dynamics and function of secondary active transporters involved in cellular homeostasis. Practically, you will design and clone targets and express and purify well-behaved constructs to subject them to single-particle cryo-EM and in vitro and ex vivo transport assays to characterize protein-ligand and protein-lipid interactions. You will develop and apply vesicle assays for further functional characterization. The position offers a mixture of techniques, and you are expected to steer the project in the required direction. You will work in a highly collaborative environment and are expected to participate in mentoring PhD students and other junior researchers in the lab.

How to Apply?

Application Method: Online Application
Ref. No.: -

Application Procedure

Your application must be written in English and submitted electronically by clicking the ‘APPLY NOW’ button below. This will prompt you to create a profile on the internal HR application system. In addition to details on your degree and formal qualifications, the application must include the following:

  1. Cover letter detailing your background and motivation for applying (max. one page).
  2. Curriculum vitae describing your education, research and work experience, language skills and other relevant skills (max. two pages).
  3. PhD certificate and Master of Science certificate or a written statement from your supervisor if your PhD is yet to be completed.
  4. Publication list including papers submitted or accepted for publication.
  5. Highlight of 1-3 of your most significant publications.
  6. Other relevant material.

About the Department/Section/Group

The successful applicant will become a member of the Autzen Lab, a young and vibrant research group part of the Linderstrøm-Lang Centre for Protein Science within the Section for Biomolecular Sciences, at the Department of Biology. Home for 11 labs specializing in cellular and protein biology, protein design or structural biology, the Section for Biomolecular Sciences is an international and multidisciplinary workplace, offering a creative and stimulating working environment.

The Autzen Lab is focused on characterizing the activation and modulation of membrane proteins involved in selected, cellular pathways to delineate their basic function and therapeutic potential. In extension, the lab is focused on developing tools for detergent-free membrane protein purification to conserve native protein-lipid interactions. The lab houses state-of-the-art facilities for mammalian protein production, purification, biochemical and biophysical characterizations, and data processing and has access to state-of-the-art cryo-EM facilities at the Core Facility for Integrated Microscopy on campus and at the iNANO Cryo-EM facility at Aarhus University.

The Autzen Lab is built on community, trust, openness, honesty, and solidarity and strives to embody the scientific method, objectivity, and reproducibility. We value open science, knowledge and data sharing and science communication to a wider audience, ultimately bridging the gap between society and research.

You can read more about the Autzen Lab and our core values on our website.

About the Employer:

Note or Other details

What we offer

  • An exciting and stimulating research project set in a creative, scientifically strong, and international academic environment.
  • An open and inclusive work environment with dedicated colleagues.
  • Room for personal and professional development.

Your duties will include research within NHEs, daily maintenance of the wet lab and establishing and/or developing new research protocols. The post may also include performance of other duties as well as teaching.

Living in Copenhagen, Denmark

Despite cold and rainy days in plenty, Denmark is among the happiest countries according to the World Happiness Report and Copenhagen is regularly ranked among top 5 cities to live in, particularly for expats. Whether you are into ancient sculptures or contemporary art, opera or heavy metal Copenhagen is ready to teach, inspire and entertain. Furthermore, with an extensive public transportation system, beautiful, tranquil nature is only minutes away from the city center.

For more information on working and living in Denmark, visit University of Copenhagen’s website on International Staff Mobility and WorkinDenmark.

The position is covered by the Memorandum on Job Structure for Academic Staff. Terms of appointment and payment accord to the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State.

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Contact details

The supervisor on the project, Associate Professor Henriette E. Autzen, welcomes informal inquiries on the position on email: henriette.autzen ( at ) bio.ku.dk.

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