Postdoc or Researcher in Position UCPH University of Copenhagen, Denmark

Postdoc position in molecular mechanisms of synaptic homeostasis at the Uni of Copenhagen, Denmark 2022

Denmark

Postdoc position in molecular mechanisms of synaptic homeostasis is available for a doctoral degree candidates in natural science or medical science at the Department of Neuroscience, University of Copenhagen (UCPH), Denmark 2022

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General Info

Position: Postdoc
No. of Positions: 1
Research Field: ,
Deadline to Apply: Expired
Joining Date: Jun 15, 2022
Contract Period: 2 Years
Salary: According to standard norms

Workplace:
Department of Neuroscience

University of Copenhagen (UCPH), Denmark

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Qualification Details

We are looking for a highly motivated and enthusiastic scientist with the following competencies and experiences:

Essential experience and skills:

  • PhD or equivalent degree in natural or medical science
  • You have an excellent scientific track record, preferably with first-author publications.
  • You hold experience in electrophysiological, optical techniques and/or Drosophila behavioural analysis.
  • You are enthusiastic, highly motivated and a self-starter.
  • Good communication skills, both oral and written.
  • Excellent English skills written and spoken.

Optional skills

  • Work experience with Drosophila melanogaster
  • Experience with biochemistry.

Responsibilities/Job Description

We seek an excellent Postdoc with a high potential for original research. The project focuses on the molecular basis for homeostatic synaptic plasticity, which is an evolutionarily conserved mechanism to ensure continuous synaptic communication in the light of interference. Disruption of this function may contribute to human disease. Using the model system Drosophila melanogaster we recently showed that members of the Unc13 protein family set the strength of a synapse and are essential for its capacity to undergo this plasticity (Reddy-Alla et al., Neuron 2017 Sep 13;95(6):1350-1364; Böhme et al., Nat Commun. 2019 Mar 6;10(1):1085). Using genetic tools, advanced super-resolution (STED) microscopy and electrophysiology we have dissected two principle components for presynaptic potentiation of synapses, one that relies on the available protein machinery for immediate plasticity and one that involves structural synapse remodeling for long-term changes (Böhme et al., Nat Commun. 2019 Mar 6;10(1):1085). However, molecular details on how these two complementary mechanisms are organized, intersect and how their disruption affects the organism are lacking. The advertised project is focused on elucidating those mechanisms and to investigate whether human disease mutations affect homeostatic mechanisms.

Your job The specific aim of the current position is to investigate mechanisms of homeostatic synaptic plasticity on immediate and long-term timescales using Drosophila melanogaster and how alterations of these mechanisms affect the organism. Moreover, it shall be investigated to what extent human disease mutations in synaptic genes affect this form of plasticity which may help understand disease mechanisms. You will participate in making a plan for the exact experiments to be performed. Together with other group members, your tasks will be to design experiments, generate flylines, perform experiments, analyze results, and write up papers.

How to Apply?

Application Method: Online Application
Ref. No.: -

Application Procedure

Your online application must be submitted in English by clicking ‘Apply now’ below. Furthermore your application must include the following documents/attachments – all in PDF format:

  1. Motivated letter of application (max. one page).
  2. CV incl. education, work/research experience, language skills and other skills relevant for the position.
  3. A certified/signed copy of a) PhD certificate and b) Master of Science certificate (if applicable), c) transcript of records, including courses followed and marks obtained. If the PhD is not completed, a written statement from the supervisor will do.
  4. List of publications.
  5. Letters of recommendation and the name of at least two references

About the Department/Section/Group

The Walter group is highly interactive and characterized by teamwork. The team is interdisciplinary and international and we welcome new team members. We study molecular principles of synaptic transmission. Besides studying the basic molecular machinery mediating neurotransmission, the lab is interested in describing plasticity mechanisms by which synapses dynamically adjust their transmission strength on various timescales. For our work we use the model system Drosophila melanogaster. This model system is easily amenable to genetic analysis, electrophysiology, light microscopy and behavioural analysis. Information on the Walter group can be found here: https://www.walter-lab.com/.

About the Employer:

Note or Other details

Terms of employment

The employment as Postdoc is a full time and fixed-term position for 2 (two) years. Starting date is 15 June 2022.

Salary, pension and terms of employment will be in accordance with the agreement between the Danish Ministry of Finance and AC (Danish Confederation of Professional Associations).Currently, the monthly salary starts at 35,000 DKK/approx. 4,700 EUR (October 2021 level). Depending on qualifications, a supplement may be negotiated. The employer will pay an additional 17.1 % to your pension fund.

Foreign and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.

The position is covered by the Job Structure for Academic Staff at Universities 2020.

Foreign applicants may find this link useful: http://www.ism.ku.dk (International Staff Mobility).

We reserve the right not to consider material received after the deadline, and not to consider applications that do not live up to the abovementioned requirements.

The further process After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the hiring committee. All applicants are then immediately notified whether their application has been passed for assessment by an unbiased assessor. Once the assessment work has been completed each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at https://employment.ku.dk/faculty/recruitment-process/.

The applicant will be assessed according to the Ministerial Order no. 242 of 13 March 2012 on the Appointment of Academic Staff at Universities.

The University of Copenhagen wish to reflect the diversity of society and encourage all qualified candidates to apply regardless of personal background.

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Contact details

For further information please contact Associate Professor Dr. Alexander Matthias Walter, Department of Neuroscience, [email protected], direct phone: +45 28752811.

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