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Postdoc or Researcher Position in Aarhus University Denmark

Postdoc position in Enzyme Discovery and Biocatalysis at Aarhus, Denmark, Mar-2022.

Denmark

Postdoctoral researcher position in Enzyme Discovery and Biocatalysis to identify and characterize metalloenzymes for oxidative defluorination by unzipping long-chain PFAS and following elimination reactions is available for applicants with doctoral degree at the Department of Engineering, Aarhus University, Denmark- March 2022.

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General Info

Position: Post Doctoral Fellow
No. of Positions: 1
Research Field: , ,
Deadline to Apply: Expired
Joining Date: ASAP
Contract Period: Subject to Norms
Salary: According to standard norms

Workplace:
Department of Engineering

Aarhus University (AU), Denmark

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Qualification Details

Required Education and Skills:

  • Completed PhD in the field of Biochemistry, Biotechnology or relevant
  • Strong background in enzyme discovery and the application of enzymes in biocatalysis
  • Practical experience in protein engineering
  • Expertise in chemical analysis (especially NMR, MS and isotopic labelling chemistry)
  • Self-motivated, pro-active, team- and goal-oriented personality
  • Full command of the English language

Experience in lipid analysis is an additional advantage.

Responsibilities/Job Description

The key tasks in this project will be:

  • Database screening and generic screening and mining for discovery of metalloenzymes for defluorination of PFAS;
  • Characterization and structural illustration of promising genotypes of enzymes for defluorination;
  • Mechanism study and enzyme engineering to evolve or redesign variants for improved PFAS-degrading activity, stability and compatibility with photocatalysts.

How to Apply?

Application Method: Online Application
Ref. No.: 8387

Application Procedure

Shortlisting is used. This means that after the deadline for applications – and with the assistance from the assessment committee chairman, and the appointment committee if necessary, – the head of department selects the candidates to be evaluated. All applicants will be notified whether or not their applications have been sent to an expert assessment committee for evaluation. The selected applicants will be informed about the composition of the committee, and each applicant is given the opportunity to comment on the part of the assessment that concerns him/her self. Once the recruitment process is completed a final letter of rejection is sent to the deselected applicants.

Letter of reference

If you want a referee to upload a letter of reference on your behalf, please state the referee’s contact information when you submit your application. We strongly recommend that you make an agreement with the person in question before you enter the referee’s contact information, and that you ensure that the referee has enough time to write the letter of reference before the application deadline.

Unfortunately, it is not possible to ensure that letters of reference received after the application deadline will be taken into consideration.

About the Department

Per- and polyfluoroalkyl substances (PFAS) have received global public attention because of their persistence, bioaccumulation, mobility in aquatic and soil systems, and possible adverse effects on living organisms. This project proposes a cascade processing strategy based on the reaction course and characteristics of substrates, affording a zero-fluoropollutant emission. New metalloenzymes will be identified and characterized for oxidative defluorination by unzipping long-chain PFAS and following elimination reactions.

The genetic sequencing, mechanism disclosure and structure-function relationships of PFAS-fluoride eliminating enzymes will be investigated by means of in silico or in vitro approaches to harness their catalytic potential for re-design and engineering of enzymes.

About the Employer:

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Contact details

For further information please contact Professor Zheng Guo and/or Assistant Prof. Zongsu Wei, email: [email protected], or [email protected]  phone: +45 87155528 or +45 93522047.

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