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Postdoc Job on cellular responses of radionuclide therapy at Erasmus MC, Netherlands 2022

The Netherlands

Postdoc Job on cellular responses of radionuclide therapy is available for doctor degree candidates in biomedical science, molecular/cellular biology, oncology, or related field at the Department of Molecular Genetics, Department of Radiology an Nuclear Medicine Erasmus MC, Netherlands 2022

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General Info

Position: Postdoc
No. of Positions: 1
Research Field: , , ,
Deadline to Apply: Expired
Joining Date: Jul 01, 2022
Contract Period: 1 years
Salary: € 4.707/month

Workplace:
Department of Molecular Genetics and the Department of Radiology and Nuclear Medicine

Erasmus MC, the Netherlands

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Qualification Details

  • You are a highly motivated and independent candidate that holds a PhD degree in biomedical science, molecular/cellular biology, oncology, or related field with a basic knowledge of the DNA damage response.
  • You should have experience with standard molecular biology techniques and confocal microscopy. Experience in radionuclide handling and drug screening will be considered an advantage.
  • You are a team-player who is able to combine independent thinking with a collaborative attitude as you will be working in a dynamic international research environment.
  • You have strong written and oral English skills.

Before you apply please check our conditions for employment.

  • You are a highly motivated and independent candidate that holds a PhD degree in biomedical science, molecular/cellular biology, oncology, or related field with a basic knowledge of the DNA damage response.
  • You should have experience with standard molecular biology techniques and confocal microscopy. Experience in radionuclide handling and drug screening will be considered an advantage.
  • You are a team-player who is able to combine independent thinking with a collaborative attitude as you will be working in a dynamic international research environment.
  • You have strong written and oral English skills.

Before you apply please check our conditions for employment.

Responsibilities/Job Description

We are looking for a talented postdoc to work on a project focusing on the radiobiology of targeted radionuclide therapy (TRT). This multidisciplinary project brings together expertise from the fields of nuclear medicine, molecular biology, cell biology and microscopy.

TRT is a promising novel modality to treat patients with metastasized cancer. TRTs function via systemic administration of radiolabeled molecules designed to target tumor cells. However, the biological radiation effects of TRTs are poorly understood, and rational design of new modalities based on underlying cellular mechanisms is therefore not possible, resulting in suboptimal treatment strategies. In this preclinical research project, you will perform in vitro experiments (cells and tissues) to identify and quantify specific radiobiological mechanisms of TRT-radiation effects.

The project will consist of 2 parts which will run in parallel: Part 1 will focus functional comparison of different TRT-targeting molecules with the aim of selecting the best molecule for future clinical testing. Part 2 will focus on identifying the cellular pathways activated by these TRT-targeting molecules with the aim to novel identify TRT-induced cellular responses and design potential combination treatments. Techniques that you will use include binding assays, autoradiography, drug screens, RNA sequencing, flow cytometry and immunofluorescent stainings. You will work closely together with a research technician and bioinformatician.

How to Apply?

Application Method: Online Application
Ref. No.: 15.01.22.TDA

Application Procedure

Your application must include the following documents:

  • Cover letter explaining your motivation and suitability for the position.
  • CV/resume including your previous positions, research projects and other relevant experience.
  • Contact information of 2 senior scientists or principal investigators including your PhD supervisor as references, willing to provide recommendation letters or enquiry.

If you are excited by the thought of this position and would like to apply, please do so by using the application form on our website.

About the Department/Section/Group

You will be positioned with a dual appointment at the Department of Molecular Genetics and the Department of Radiology and Nuclear Medicine in the research team of Dr. Julie Nonnekens. The group uses a multidisciplinary approach to advance understanding of the underlying cellular mechanisms of TRTs with the aim to improve current treatment regimens or invent new ones. Research in the group ranges from cells to animals, and from computational models to clinical studies.

The Department of Molecular Genetics has a long history and strong world-wide reputation in understanding mechanisms of disease formation from the molecular level to physiological processes in the body in the context of cancer, aging and aging-related diseases. Multidisciplinary research teams perform basic and applied research ranging from the single molecule level up to complete organisms and patient derived materials employing state-of-the-art technologies, including genomics, proteomics, bioinformatics, bioimaging and transgenesis.

The Department of Radiology & Nuclear Medicine of the Erasmus MC is dedicated to high quality patient care, education, and research. Concerning research, the department is known for its forefront research and its state-of-the-art facilities. TRT for neuroendocrine tumors was developed in the department and the preclinical research group has successfully developed and tested various other new radiopharmaceuticals or combinatory treatments from bench to bedside.

About the Employer:

Note or Other details

You will receive a temporary position for 1 year with a potential extension for 1 additional year. The envisioned starting date is 1st of July 2022. The gross monthly salary has a maximum of € 4.707,- (scale 10), depending on your level of education and relevant experience, based on a full time working week of 36 hours. The terms of employment are according to the Collective Bargaining Agreement for Dutch University Medical Centers (CAO UMC).

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Contact details

For more information about this position, please contact Dr. Julie Nonnekens, project leader, e-mail: [email protected]. For queries regarding your application, please contact Jerry Chandansingh, Recruiter, +31 (0)6 500 310 06.

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