The Hubrecht Institute invites applications for a Ph.D. student position work on Genomic instability in Fanconi Anemia at the single cell level at the Garaycoechea group, the Netherlands – Mar 2022

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General Info

Position: PhD Position
No. of Positions: 1
Research Field: , ,
Deadline to Apply: Expired
Joining Date: ASAP
Contract Period: 1 Year
Salary: 2.443 EURO/Month

Workplace:
Garaycoechea group

Hubrecht Institute, Netherlands

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Qualification Details

We are looking for an outstanding PhD candidate (MSc or equivalent qualification) with a strong background in molecular biology, genetics and/or bioinformatics. The candidate should be passionate about biology and be motivated to work in an ambitious, multidisciplinary and international research team. The working language in our international team is English, the candidate should therefore have excellent English communication skills and be able to work as part of a team.

Responsibilities/Job Description

Fanconi Anaemia (FA) is a rare disease caused by genetic defects in DNA repair. FA is the most common cause of inherited bone marrow failure, these patients also frequently develop myelodysplasia (MDS) and have an extreme predisposition to acute myeloid leukaemia (AML) – two pathologies characterised by loss bone marrow genome stability leading to abnormal karyotypes.

In this proposal we aim to assess karyotypic abnormalities at single nucleotide resolution. We will build upon our previous findings in mice, that have shown spontaneous genome instability in the bone marrow compartment. Using novel single cell sequencing techniques we will determine the frequency and also the pattern of chromosomal aberrations in the blood and bone marrow. We will combine this new technique with mouse genetics to probe the mechanics of how these chromosome breaks arise in this devastating human disease. We will use clinical samples from human FA patients to potentially develop novel biomarkers to determine the degree of genome instability but also to detect the emergence of recurrent aberrations. This project will shed light on the origins of genomic during haematopoiesis, and will guide clinicians in the treatments of bone marrow failure and MDS/AML.

How to Apply?

Application Method: Send Email
Ref. No.: HUBR-2022-02 

Application Procedure

Please send your application before March 13th 2022, including curriculum vitae and contact details of two potential references to [email protected], stating vacancyHUBR-2022-02 in the subject line, respectively.

About the Employer:

Note or Other details

Duration: 1 year with the possibility of an extension for three years after positive evaluation.Salary: According to “CAO-Nederlandse Universiteiten” (CAO-NU) € 2.443,- in the first year, increasing to € 3.122,- in the fourth year, excluding 8% holiday allowance and an 8.3%year-end bonus. We offer an extensive package of fringe benefits.Location: Utrecht Science Park, the Netherlands.

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Contact details

For additional information please contact Dr. Juan Garaycoechea [email protected] or visit the website www.hubrecht.eu.

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