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PhD Student Position in Epigenetics – Hubrecht Institute, Netherlands, Mar 2022

The Netherlands

The Hubrecht Institute invites applications for a Ph.D. student position to work on Oxidative demethylation as a source of DNA damage, at the Garaycoechea group, the Netherlands – Mar 2022

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General Info

Position: PhD Position
No. of Positions: 1
Research Field: , ,
Deadline to Apply: Expired
Joining Date: ASAP
Contract Period: 1 Year
Salary: 2.443 EURO/Month

Workplace:
Garaycoechea group

Hubrecht Institute, Netherlands

,

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Qualification Details

We are looking for an outstanding PhD candidate (MSc or equivalent qualification) with a strong background in molecular biology, genetics and/or bioinformatics. The candidate should be passionate about biology and be motivated to work in an ambitious, multidisciplinary and international research team. The working language in our international team is English, the candidate should therefore have excellent English communication skills and be able to work as part of a team.

Responsibilities/Job Description

Description of the project:‘Epigenetics’ refers to the way in which cells transmit information without altering the DNA sequence. The methylation of cytosine in the mammalian genome is a key epigenetic modification that has a profound impact on gene expression, development, imprinting, transposon silencing and cancer. The oxidised forms of 5-methylcytosine (5mC) have emerged as biologically important intermediates of DNA demethylation, which is carefully regulated during development. We have recently discovered that one such oxidised form of 5mC, 5-hydroxylmethylcytosine (5hmC), is extremely toxic to cells lacking certain DNA repair pathways. In parallel, preliminary data also shows that mice lacking the same repair factors have profound defects in the number of primordial germ cells (PGCs), the cell population that goes through extensive epigenetic reprogramming in order to give rise to the germline. These data suggest that oxidative demethylation can threaten genome integrity and cell viability.

In this project, we will use a three-pronged approach to ask if oxidation of 5mC is a source of DNA damage and how this damage is counteracted. By combining genetics (in cells and mice), with biochemistry and single cell sequencing, we aim to understand the mechanism by which oxidative demethylation may induce genotoxicity. We will explore how the oxidation of DNA threatens genome stability and how repair processes counteract that threat. These findings will shed light on the mechanisms that ensure proper development and may also have an impact on the improvement of iPSC-based therapies.

How to Apply?

Application Method: Send Email
Ref. No.: HUBR-2022-01

Application Procedure

Please send your application before March 13th, 2022, including curriculum vitae and contact details of two potential references to [email protected], stating vacancyHUBR-2022-01 in the subject line, respectively.

About the Employer:

Note or Other details

Duration: 1 year with the possibility of an extension for three years after positive evaluation.Salary: According to “CAO-Nederlandse Universiteiten” (CAO-NU) € 2.443,- in the first year, increasing to € 3.122,- in the fourth year, excluding 8% holiday allowance and an 8.3%year-end bonus. We offer an extensive package of fringe benefits.Location: Utrecht Science Park, the Netherlands.

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Contact details

For additional information please contact Dr. Juan Garaycoechea [email protected] or visit the website www.hubrecht.eu.

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