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PhD position in Molecular biology, Biochemistry, Genetics – Lund, Sweden

Lund University

Sweden

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Nov 4, 2021 23:59 (GMT +2)

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Faculty of Medicine, Department of Experimental Medical Science invites applications for a PhD position in molecular biology, Sweden – Nov 2021

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General Info

Position: PhD position
No. of Positions: 1
Research Field: , ,
Deadline to Apply: November 4, 2021(GMT +2)
Joining Date: ASAP
Contract Period: 4 Years
Salary: According to Standard Norms

Workplace:
Faculty of Medicine
Department of Experimental Medical Science
Lund University
Lund,

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Qualification Details

Required qualifications 

-Familiarity with molecular microbiology techniques

-Familiarity with recombinant DNA technology

-Background understanding of molecular biology, biochemistry and genetics

-Proficiency in spoken and written English

Desired qualifications 

-Experience in working with bacteriophages

-Experience in protein and / or RNA biochemistry

-Experience in microbiological and biological analysis of protein synthesis

-Experience in microbiological and biological analysis of toxin-antitoxin systems

Responsibilities/Job Description

In this PhD project you will be a part of the project that will focus on toxin-antitoxin systems, but you will also have opportunities to broaden your horizons and work on other molecular systems studied in the lab.

You will have the opportunity to attend and present your work at international meetings.

How to Apply?

Online Application through "Apply Now" Button from this page or from advertisement webpage (URL below)

Reference Number: PA2021/3123
(If any, use it in the necessary place)

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Documents Required

-A cover letter explaining your interest in the project and your previous relevant experience

-A full CV with contact details of two referees

-Bachelors and Masters certificates

About the Project/Department

In the Hauryliuk lab we work on deciphering the molecular mechanisms implicated in bacterial virulence, tolerance to stress, resistance to antibiotics, and refractivity to phage infection [1-5]. We use a powerful combination microbiological, biochemical, functional genomics and structural biology techniques, and work in close collaboration with the bioinformatics group of Gemma C. Atkinson (see https://atkinson-lab.com/ ). The joint lab is based in the Department of Experimental Medical Sciences in the Biomedical Centre (BMC) in Lund. You can learn more about the department here: https://www.medicine.lu.se/faculty-medicine-lund-university/departments/department- experimental-medical-science

One of the research directions in the lab is study of toxin-antitoxin (TA) systems of bacteria and bacteriophages. One of the novel TA toxins discovered in the lab are so-called toxSAS enzymes that inhibit bacterial growth though producing poisonous nucleotides (see our recent paper in PNAS [4]) or modifying tRNA (see our recent paper in Molecular Cell [5]). In 2020, our work on discovering and characterizing novel toxin-antitoxins was supported by a generous grant from the Knut and Alice Wallenberg foundation (see se https://kaw.Wallenberg.org/grundforskning-djupt-inne-i-bakteriernas-arvsmassa, in Swedish). The fundamental studies of TAs lay the foundation for developing them into new biotechnological tools. Since TAs constitute a mechanism of defence against bacteriophages, our research also important for understanding and eventually overcoming natural barriers to phage therapy for treating antibiotic resistant infections.

We are looking for an experimental full-time PhD student to work our explorative toxin-antitoxin research program. In our group, we strive for a supportive, respectful and stimulating working environment that promotes personal and professional development for all members.

Start date is by agreement.

References

  1. Roghanian M. et al. Molecular Cell, 81(16), 3310-3322.e6 (2021)
  2. Crowe-McAuliffe C. et al. Nature Communications, 12(1):3577 (2021)
  3. Crowe-McAuliffe C. et al. Molecular Cell, 81(1):115-126.e7 (2021)
  4. Jimmy S. et al. Proc Natl Acad Sci U S A 117, 10500-10510, (2020)
  5. Kurata T. et al. Molecular Cell 81, 3160-3170 e3169, (2021)

About the Employer: Lund University

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Contact details

  • Vasili Hauryliuk, Research group leader, +460706090493
  • Sofia Sönnerstedt, HR coordinator, +46462229876

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