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PhD position in Computational science, specialization of chemistry – Umea, Sweden – Oct 2021

Umeå University (UMU)

Sweden

The Department of Chemistry is seeking a PhD-student in computational science with a specialization in chemistry – Umea University, Sweden, Oct 2021.

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General Info

Position: PhD
No. of Positions: 1
Research Field: ,
Deadline to Apply: Expired
Joining Date: -
Contract Period: Not Mentioned
Salary: According to Standard Norms

Workplace:
-
Department of Chemistry
Umeå University (UMU)
Umeå,

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Qualification Details

To be admitted for studies at third-cycle level the applicant is required to have completed a second-cycle level degree, or completed course requirements of at least 240 ECTS credits, of which at least 60 ECTS credits are at second-cycle level or have an equivalent education from abroad, or equivalent qualifications.

To fulfil the specific entry requirements to be admitted for studies at third-cycle level in chemistry, the applicant is required to have completed at least 90 ECTS credits in computational science and engineering courses, of which at least 30 ECTS credits shall have been acquired at second-cycle level. Computational science and engineering courses refers to courses with major quantitative, statistical or computing science elements, such as courses in computing science, mathematics and mathematical statistics, and relevant courses in biology, ecology, physics and chemistry. Applicants who in some other system either within Sweden or abroad have acquired largely equivalent skills are also eligible.

Good knowledge in English, both written and spoken, is required. The candidate is able to work in a structured and solution-oriented way, and is interested in learning new things, especially in Advanced Data Analytics area. Very good communication skills and the ability to work in a team are also requirements.

Experience with design of experiment, multivariate data analysis tools and statistics is a merit as well as thorough understanding and hands-on experience in application of modern high-resolution methods for analysis of biological samples.

Responsibilities/Job Description

According to the lab interest

How to Apply?

Online Application through "Apply Now" Button from this page or from advertisement webpage (URL below)

Reference Number: -AN 2.2.1-1352-21
(If any, use it in the necessary place)

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Documents Required

A complete application should contain the following documents:

  • A cover letter including a description of your research interests and motivation for applying
  • A Curriculum Vitae
  • Certified copies of degree certificates or equivalent, including documentation of completed academic courses and obtained grades

About the Project

Biologics are a class of medications that have already had a profound impact on many medical fields, primarily rheumatology and oncology, and have expanded therapeutic options for the treatment of a wide range of diseases. Biologics are commercially produced by living cells, a process being inherently complex, partly due to the current lack of understanding of the factors influencing it, that impact product efficiency and quality.

The presented project will focus on modelling of high-throughput omics data from the characterization of main biopharmaceutical production processes, based on the Chinese Hamster Ovary (CHO) cell line. This with the aim to obtain enhanced understanding of the process on a molecular level, which will contribute to the future optimization of to improve the production of biologics.

The main challenge in industrial processes based on complex biological systems is efficient real-time monitoring, control and prediction of the process outcome. Mathematical models are quite often used for these purposes. For the duration of the project we will apply and develop modern data analytics approaches based on multivariate data analysis methods for characterization of normal and deviating evolution of cellular metabolism during biomanufacturing processes.

The project will be performed in collaboration with Sartorius, a total solutions provider for the modern biopharmaceutical industry and a world leader in industrial process monitoring and control using multivariate technology. The candidate will have the possibility to spend parts of the project time in the Sartorius office in Umeå where you will interact with other Sartorius members, including developers and data scientists. Furthermore, you will be given the opportunity for several on-site visits to the Sartorius bioprocessing lab in Göttingen, where all experiments will be done, and to Sartorius Cellca, to interact with people developing commercial CHO cell lines.

About the Department

The Department of Chemistry is one of the largest departments within the Faculty of Science and Technology with approximately 200 employees, of which approximately 50 doctoral students, and a strong and expanding research. The Department has three major research areas: Biological Chemistry, Environmental and Biogeochemistry, and Technical Chemistry. We are also a strong partner in the KBC, Chemical-Biological Center. Information about the postgraduate education can be found on the Faculty of Science and Technology website:

www.umu.se/en/faculty-of-science-and-technology/education/doctoral-studies/chemistry/.

For more information about working at Umeå University,

https://www.umu.se/en/work-with-us/ .

About the Employer: Umeå University (UMU)

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Contact details

For more information please contact Professor Henrik Antti, henrik.annti@umu.se.

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