PhD Position Aarhus University Denmark

Ph.D. Position in Health Science at Aarhus University, Denmark 2022

Denmark

Ph.D. Position in Androgen replacement therapy in women with Turner Syndrome – Endocrine, cardiovascular, physiological and neurocognitive effects is available for master’s degree candidates in Health Science at the Graduate School of Health, Aarhus University, Denmark 2022

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General Info

Position: PhD
No. of Positions: 1
Research Field:
Deadline to Apply: Expired
Joining Date: ASAP
Contract Period: Subject to Norms
Salary: According to standard norms

Workplace:
Graduate School of Health

Aarhus University (AU), Denmark

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Qualification Details

Qualified physician, preferably with prior research experience. Fluent Danish language proficiency will be required in order to communicate seamlessly with involved patients.

Responsibilities/Job Description

Women born with Turner Syndrome (TS) are genetically characterized by either a complete or partial loss of one X chromosome. Most women with TS suffer from primary or secondary hypergonadotropic hypogonadism, necessitating estrogen replacement therapy (ERT) from the age of 12 to the average age of menopause. Numerous studies have elucidated the effects of ERT in women with TS and the beneficial effects on morbidity, as well as on general health and well-being. However, only few studies have focused on the impact of androgen insufficiency in women with TS.

In healthy women, androgens are produced in the ovaries and the adrenal glands, each gland contributing equally to the circulating pool of androgens. In women, as in men, testosterone is considered important for pubertal development, sexual function, body composition, erythropoiesis, neurocognitive functioning and mood. In TS women, testosterone is decreased with up to 50% due to gonadal dysfunction. Furthermore, estrogen replacement therapy is thought to influence the androgens levels negatively, adding to the androgen deficit.

During the past decades, attention towards the importance of androgens in women has gained traction. Treatment of hypoactive sexual desire, with testosterone, in postmenopausal women has been endorsed. However, androgens affect more than just sexual behavior and maintenance of secondary sexual characteristics in women. A randomized, double-blinded, placebo-controlled study investigated the effects of androgen replacement therapy in TS women. They found that one year of treatment with orally administrated testosterone improved body composition, neurocognition and quality of life, along with a decrease in cholesterol levels.

Objectives

To investigate the endocrine, cardiovascular, physiological and neurocognitive effects of transdermal androgen replacement therapy, as a supplement to estrogen replacement therapy, in women with TS.

How to Apply?

Application Method: Online Application
Ref. No.: -

Application Procedure

For information about application requirements and mandatory attachments, please see our application guide.

About the Employer:

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Contact details

Please contact Professor Claus H. Gravholt, [email protected], for more information.

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