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Ph.D. Position in Functional Genomics at University of Lausanne, Switzerland 2022

Switzerland

Ph.D. Position in Functional Genomics is available for Master’s degree candidates in biology at Van Leeuwen lab, University of Lausanne, Switzerland 2022

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General Info

Position: PhD
No. of Positions: 1
Research Field: ,
Deadline to Apply: Expired
Joining Date: ASAP
Contract Period: 4 years
Salary: According to standard norms

Workplace:
Van Leeuwen lab

University of Lucerne (UNILU), Switzerland

,

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Qualification Details

We are looking for talented students interested in high-throughput genetic analysis, with a specific focus on suppression. A Master’s degree in biology or a related discipline is required, and a background in yeast genetics or functional genomics is a plus. Exceptional interest in understanding genetic interactions and a great sense of teamwork are essential.

Responsibilities/Job Description

The primary research mission of the Van Leeuwen lab is to use functional genomics tools to improve our understanding of how mutations can interact to produce unexpected phenotypes, and how this determines the severity of genetic traits. Our research focusses explicitly on suppression interactions, in which the accumulation of secondary mutations elsewhere in the genome can compensate for the deleterious effects of the primary mutation. We previously mapped a first global suppression network in yeast in order to discover the general principles underlying these interactions [van Leeuwen et al. (2016) Science, 354, 599]. Deciphering the general rules of suppression interactions in yeast may allow us to predict these interactions in human genomes. For human disease genes, suppressors can represent strong targets for therapeutic intervention.

The candidate will be expected to conduct research within the context of the lab’s research goal. Projects generally involve high-throughput genetic screens in either yeast (using robotics) or cultured human cells (using CRISPR-Cas9 gRNA libraries). The successful candidate will also be expected to accurately execute experiments to validate discoveries from primary genetic screens. The candidate will contribute to manuscripts for publication and present research findings at academic conferences. Funding for the position is available, but applications to fellowship programs will be highly encouraged.

How to Apply?

Application Method: Online Application
Ref. No.: 19656

Application Procedure

Please submit your full application comprising:

­- a cover letter detailing your research interests and experience, and clearly explaining why you are interested in this particular position

­- a CV

­- contact details for 2 or more referees

Only applications received through this website will be considered.

We thank you for your understanding

About the Employer:

Note or Other details

Expected start date in position: September 1st, 2022

Contract length: 1 year, renewable for maximum 4 years

Activity rate: 100% (a minimum of 50% of the activity rate for research, a maximum of 50% of the activity rate for the institutional tasks)

Workplace: University of Lausanne, Dorigny

offers you

The Van Leeuwen lab is hosted at the Center for Integrative Genomics: a vibrant, well­-funded institute with a focus on genomics research, and equipped with modern core facilities (see www.unil.ch/cig). It is embedded in the broader Lausanne research environment that includes two higher education institutions (UNIL, EPFL), the Swiss Institute of Bioinformatics, the Ludwig Center for Cancer Research, the University Hospital, and a cluster of biotech companies flourishing in the larger Lake Geneva area. We offer an international, multidisciplinary, and dynamic academic environment. The Ph.D. student will be enrolled in the Faculty of Biology and Medicine’s doctoral school

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Contact details

Informal inquiries should be sent to Prof. Jolanda van Leeuwen: [email protected]

Website: http://www.vanleeuwenlab.com

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