PhD position at Delft University of Technology TUDelft, The Netherlands

Ph.D. Position in Biophysics, biochemistry at TU Delft, Netherlands 2022

The Netherlands

Ph.D. Position in Dynamics of proteins in cell nuclei studied by super-resolution microscopy is available for master’s degree candidates in biophysics, biochemistry at the Faculty of Applied Sciences, Delft University of Technology (TU Delft), Netherlands 2022

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General Info

Position: PhD
No. of Positions: 1
Research Field: ,
Deadline to Apply: Expired
Joining Date: ASAP
Contract Period: 4 years
Salary: € 2,443.00 - € 3,122.00/month

Faculty of Applied Sciences

Delft University of Technology (TU Delft), the Netherlands


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Qualification Details

We are seeking an outstanding experimental scientist with a strong interest in research at the interface of physics and biology. Research experience in fields such as biophysics, single-molecule techniques, optical microscopy, nanoscience or related is highly desired. We are looking for a team-player who can work independently and has a genuine interest in fundamental research.

Applicants must:

  • Hold a Master's degree, or approach its completion, in (bio)physics, biochemistry, engineering, nanoscience, or a closely related discipline
  • Have excellent written and spoken English skills
  • Thrive in an international and multidisciplinary team

Doing a PhD at TU Delft requires English proficiency at a certain level to ensure that the candidate is able to communicate and interact well, participate in English-taught Doctoral Education courses, and write scientific articles and a final thesis. For more details please check the Graduate Schools Admission Requirements.

Responsibilities/Job Description

In order to keep human bodies healthy, cells have to continuously adjust to stress, such as DNA damage, nutrient deficiency and mechanical stress. Recently, the lamin family of cytoskeletal proteins have emerged as a key regulator of cell response to intrinsic and environmental stimuli. Lamins are the main architectural proteins of the nucleus and form a fibrous, highly stable meshwork underlying the inner nuclear membrane. The cell's stress response triggers one of the lamin types, prelamin A, to accumulate, which affects important cellular processes such as cell cycle progression, DNA-replication, chromatin remodeling and senescence.

Fundamental knowledge on the lamin-dependent regulatory mechanism that controls DNA replication, and replication fork stalling leading to cell senescence, is still lacking. DNA replication is a process fundamental to all life, and lamins have been found to regulate DNA replication through local chromosome compaction and direct interaction with the replication proteins. Furthermore, during S phase, the nucleoplasmic distribution of lamins changes with altering patterns of DNA replication. This suggests an important role in the highly complex logistics of organizing the replication of a megabase genome distributed over dozens of chromosomes. In this project, we aim to obtain fundamental understanding of the lamin-regulated replication fork positioning and stalling which could greatly enhance our knowledge of pathogenic conditions underlying ageing and cancer.

We, the Geertsema lab, are an experimental biophysics lab employing fluorescent imaging techniques to improve understanding of cellular structures at the nanometer scale. As a recently started research group, we offer an interactive, supportive and collegial environment. We perform multidisciplinary research where we combine techniques from biophysics, microscopy, cell biology, biochemistry and protein engineering.

The Geertsema lab is embedded in the Imaging Physics Department of the TU Delft, which focuses on developing and implementing novel imaging technologies. The department features an inspiring, welcoming and pioneering environment for researchers that want to push the boundaries and implementation of current imaging systems.

How to Apply?

Application Method: Online Application
Ref. No.: TUD02276

Application Procedure

Are you interested in this vacancy? Please apply before May 31st, 2022 via the application button and upload your motivation and CV.

  • A pre-employment screening can be part of the selection procedure.
  • Applying for an exemption for specific research and educational areas is an obligatory part of the selection procedure for this vacancy. This exemption must be obtained from the Ministry of Education, Culture and Science (OCW) before an employment contract is agreed upon. Click here for more information.
  • You can apply online. We will not process applications sent by email and/or post.
  • Acquisition in response to this vacancy is not appreciated.

About the Department/Section/Group

Faculty Applied Sciences

With more than 1,000 employees, including 135 pioneering principal investigators, as well as a population of about 3,400 passionate students, the Faculty of Applied Sciences is an inspiring scientific ecosystem. Focusing on key enabling technologies, such as quantum- and nanotechnology, photonics, biotechnology, synthetic biology and materials for energy storage and conversion, our faculty aims to provide solutions to important problems of the 21st century. To that end, we train students in broad Bachelor's and specialist Master's programmes with a strong research component. Our scientists conduct ground-breaking fundamental and applied research in the fields of Life and Health Science & Technology, Nanoscience, Chemical Engineering, Radiation Science & Technology, and Engineering Physics. We are also training the next generation of high school teachers and science communicators.

Click here to go to the website of the Faculty of Applied Sciences.

Additional information

Department Research in the department of Imaging Physics is aimed at developing novel instrumentation and methodology in imaging science and sensing technology. Our research products extend existing boundaries in terms of spatial resolution, temporal resolution and information/data throughput. We are pioneers in developing advanced concepts of computational imaging, a marriage between cleverly designed imaging systems and sophisticated post-processing. In everything we do, there is a core of cutting-edge physics and engineering of high-tech instruments, of the use of the most advanced computing techniques, and of a very close link to real-life applications. Our work has clear societal impact in the areas of life sciences, healthcare, and industry.

About the Employer:

Note or Other details

Doctoral candidates will be offered a 4-year period of employment in principle, but in the form of 2 employment contracts. An initial 1,5 year contract with an official go/no go progress assessment within 15 months. Followed by an additional contract for the remaining 2,5 years assuming everything goes well and performance requirements are met.

Salary and benefits are in accordance with the Collective Labour Agreement for Dutch Universities, increasing from € 2443 per month in the first year to € 3122 in the fourth year. As a PhD candidate you will be enrolled in the TU Delft Graduate School. The TU Delft Graduate School provides an inspiring research environment with an excellent team of supervisors, academic staff and a mentor. The Doctoral Education Programme is aimed at developing your transferable, discipline-related and research skills.

The TU Delft offers a customisable compensation package, discounts on health insurance and sport memberships, and a monthly work costs contribution. Flexible work schedules can be arranged. For international applicants we offer the Coming to Delft Service and Partner Career Advice to assist you with your relocation.

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Contact details

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