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Master thesis in Aggregation mechanisms of proteins in liquid formulations – Biotechnology, Sweden

RISE Research Institutes of Sweden

Sweden

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Nov 7, 2021 23:59 (GMT +1)

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Master thesis: Aggregation mechanisms of proteins in liquid formulations is available at the Department of Biological Pharmaceuticals, RISE Research Institute of Sweden – Sweden, Nov 2021

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General Info

Position: Internships
No. of Positions: 1
Research Field: , ,
Deadline to Apply: November 7, 2021(GMT +1)
Joining Date: -
Contract Period: 3-6 months
Salary: According to Standard Norms

Workplace:
Malvinas vag 3
Department of Biological Pharmaceuticals
RISE Research Institutes of Sweden
Stockholm,

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Qualification Details

For this diploma work, the student should be enrolled in a master's program in pharmacy, biotechnology/chemical engineering, or similar, and preferably have background knowledge on protein structure and drug formulation.

Responsibilities/Job Description

To evaluate how non-native proteins act as seeding points for aggregation in the bulk solution. The study will consider thermal stability, size distribution, and concentration using techniques like micro-DSC, DLS, UV-Vis. AF4 and miniTEM might be used as complementary techniques.

How to Apply?

Online Application through "Apply Now" Button from this page or from advertisement webpage (URL below)

Reference Number: -
(If any, use it in the necessary place)

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Documents Required

Documents required to complete the online application process

About the Project

Biological pharmaceuticals are a growing segment of new drugs reaching the market. They have many benefits over small molecule drugs, such as higher specificity and lower toxicity. However, some challenges still need to be studied further to develop stable, safe, and effective drugs. Aggregation and particle formation in liquid formulations affect the long-term stability and can cause issues with loss of efficacy and immunogenicity. In this project, you will work with therapeutic proteins and study the mechanism behind aggregation and particle formation.

About the Employer: RISE Research Institutes of Sweden

Note or Other details

Interviews with candidates will be conducted continuously, and acceptance can be made at any point.

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Contact details

For questions and more information, please contact Amanda Västberg, +46 10 516 59 85.

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