Karolinska, Sweden – Research Assistant position in Genomics – Oct 2021

Karolinska Institute (KI)

Sweden

A Research Assistant position in Genomics is immediately available in the Bienko and Crosetto lab for Quantitative Genome Biology at the Science for Life Laboratory (SciLifeLab) in Stockholm.

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General Info

Position: Research Assistant
No. of Positions: 1
Research Field: , , , ,
Deadline to Apply: Expired
Joining Date: ASAP
Contract Period: Not Mentioned
Salary: According to Standard Norms

Workplace:
Bienko and Crosetto lab
Karolinska Institutet
Karolinska Institute (KI)
Solna,

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Qualification Details

Are you a curious and creative person who likes to work at the bench and experiment? Do you want to develop knowledge and skills in the exciting field of 3D genome biology? Are you meticulous, attentive to detail, analytical, and self-critical? Then you are the right person!

If you have previously worked with NGS techniques, that’s great! However, we also welcome applications from people without prior experience in NGS who have a demonstrated track record of working with molecular biology and protein biochemistry techniques.

To be eligible for this position, you must hold a bachelor and/or master’s degree in biology, biotechnology, bioengineering, medicine, biomedicine or equivalent.

Responsibilities/Job Description

The GPSeq method, which we recently developed, allows studying how DNA is radially distributed in the nucleus and how genomic regions located in different parts of the nucleus are differentially prone to mutate.

We are now further expanding the scope of GPSeq to map the nuclear arrangement of RNAs and proteins, ultimately aiming at generating an atlas of the arrangement of all chromatin constituents in the nucleus of different cell types.

Your primary task will be working with other experimentalists in the lab, to develope newer versions of GPSeq specifically designed to profile RNAs and proteins radially in the nucleus.

You will be trained in GPSeq and various microscopy imaging techniques, which we routinely use to explore at the single cell level chromatin arrangement patterns revealed by GPSeq.

At the same time, you will have the opportunity to work alongside computational scientists, learning to apply advanced bioinformatic approaches to gain insight into the complex data that we generate with our methods.

How to Apply?

Online Application through "Apply Now" Button from this page or from advertisement webpage (URL below)

Reference Number: -
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Documents Required

An employment application must contain the following documents in English:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)
  • Verification from the thesis defence committee or the equivalent (only if the thesis defence is scheduled within three months after the application deadline)

About the Project/Department

As a Research Assistant, you will be working alongside other team members to further develop the GPSeq method, which our lab has recently established to profile the radial arrangement of the genome in the cell nucleus (Girelli et al, Nat Biotech 2020).

Specifically, we aim at adapting GPSeq to profile the radial distribution of RNAs and proteins in the nucleus, and your task will be optimizing different strategies, which we are implementing towards this goal.

You will be embedded in a dynamic research environment focused on 3D genome biology, molecular methods development and oncogenomics (https://bienkocrosettolabs.org/). You will work alongside senior scientists, postdocs and PhD students from many diverse fields and backgrounds, having the opportunity to learn new concepts in biology, developing your experimental skills, and fostering your creativity.

About the Employer: Karolinska Institute (KI)

Note or Other details

Karolinska Institutet is one of the world's leading medical universities. Our vision is to pursue the development of knowledge about life and to promote better health for all. At Karolinska Institutet, we conduct innovative medical research and provide the largest range of biomedical education in Sweden. Karolinska Institutet is a state university, which entitles employees to several benefits such as extended holiday and a generous occupational pension. Employees also have free access to our modern gym and receive reimbursements for medical care.

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Contact details

Magda Bienko, magda.bienko@ki.se

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