DTU PhD fellowship in Organic Chemistry, Medicinal Chemistry

University of Copenhagen (UCPH)


We are offering a three-year PhD fellowship is available from 1 February 2022 in Design and Synthesis of Peptide-based Antimicrobials., at Faculty of Health and Medical Sciences (SUND), UCPH, Denmark

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General Info

Position: PhD fellowship
No. of Positions: 1
Research Field: , ,
Deadline to Apply: Expired
Joining Date: Feb 01, 2022
Contract Period: 3 Years
Salary: 27,800 DKK/Month

Faculty of Health and Medical Sciences (SUND)
Department of Drug Design and Pharmacology
University of Copenhagen (UCPH)

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Qualification Details

As an applicant you must have:

  • qualifications corresponding to a master’s degree in Organic Chemistry,  Medicinal Chemistry or related areas prior to the starting date. The master’s degree must be equivalent to a Danish master’s degree.
  • Fluency in English and excellent communication skills

Preferred qualifications

  • Experience in peptide and/or solid-phase chemistry
  • Experience in preparative organic synthesis
  • Experience with analytical methods: NMR, HPLC and MALDI-TOF

Key criteria for the assessment of applicants

  • Professional qualifications relevant to the PhD project
  • Relevant work experience
  • Publications
  • The grade point average achieved
  • Other professional activities
  • Language skills
  • The successful applicant is also required to be enterprising and to possess good interpersonal skills

Responsibilities/Job Description

Your key tasks as a PhD fellow at the Faculty of Health and Medical Sciences are to:

  • Carry through an independent research project under supervision
  • Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points
  • Participate in active research environments including a stay at another research institution, preferably abroad
  • Obtain experience with teaching and other types of dissemination related to your PhD project
  • Participate in the undergraduate teaching of students in pharmaceutical sciences
  • Participate in national and international conferences and scientific meetings
  • Write a PhD thesis on the grounds of your research project

How to Apply?

Online Application through "Apply Now" Button from this page or from advertisement webpage (URL below)

Reference Number: -
(If any, use it in the necessary place)

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Documents Required

Your application, in English, must be submitted electronically by clicking “Apply now” below and must include the following documents in PDF format:

  • Motivated letter of application (max. one page)
  • CV incl. education, experience, language skills and other skills relevant for the position
  • Certified copy of original Master of Science diploma and transcript of records in the original language, including an authorized English translation if issued in other language than English or Danish. If not completed, a certified/signed copy of a recent transcript of records or a written statement from the institution or supervisor is accepted.As a prerequisite for a PhD fellowship employment, your master’s degree must be equivalent to a Danish master’s degree. We encourage you to read more in the assessment database: https://ufm.dk/en/education/recognition-and-transparency/find-assessments/assessment-database. Please note that we might ask you to obtain an assessment of your education performed by the Ministry of Higher Education and Science.Applicants with a Master´s degree from abroad should also enclose a short description of the grading scale used
  • Publication list (if possible)
  • Other information to consider: References and recommendations (if possible)

About the Project

The PhD project is entitled 'Exploration of peptides derived from bacterial toxin-antitoxin systems as potential antibiotics'. The project involves design and synthesis of analogues of recently identified hit compounds derived from the toxin part of bacterial toxin-antitoxin systems. Focus will be on modifications that improve bacterial uptake, while minimizing toxicity toward mammalian cells. Also, incorporation of unnatural residues will be explored as a means of increasing stability toward enzymatic degradation to improve bioavailability in vivo. The biological evaluation of the target compounds will be performed by collaborators in Norway and/or outsourced to external providers.

Experience in preparative organic synthesis and chromatographic methods is desired. A candidate with experience within peptide chemistry (e.g. manual and automated solid-phase synthesis) and relevant analytical methods (NMR, HPLC and MALDI-TOF) is preferred.

About the Department

The work will be closely integrated with related projects in a research group, focusing on discovery and improvement of therapeutics for infectious diseases and cancer. The applicant is expected to possess an outgoing interdisciplinary approach toward collaboration with researchers with a joint focus of research. Currently, the research group comprise both postdocs, PhD students and MSc students and a lab technician.

The Department of Drug Design and Pharmacology (www.drug.ku.dk) delivers drug-related research and research-based teaching within a wide range of drug-related disciplines, spanning the molecular, cellular, and pharmacological levels.

About the Employer: University of Copenhagen (UCPH)

Note or Other details

It is conditioned upon the applicant’s successful enrolment as a PhD student at the Graduate School at the Faculty of Health and Medical Sciences, University of Copenhagen. This requires submission and acceptance of an application for the specific project to the Graduate School of Health and Medical Sciences.

Salary, pension and terms of employment are in accordance with the agreement between the Ministry of Finance and The Danish Confederation of Professional Associations on Academics in the State. Depending on seniority, the monthly salary begins around DKK 27,800 (approx. 3,700 EUR) (taxable) plus pension (October 2021 level).

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Contact details

For further information, applicants may contact the principal supervisor Associate Professor Henrik Franzyk, e-mail:  henrik.franzyk@sund.ku.dk, direct phone: +45 3533 6255, or PhD coordinator Marianne W. Jørgensen, e-mail: marianne.joergensen@sund.ku.dk, direct phone: +45 3533 6449.

For more information on working and living in Denmark visit http://ism.ku.dk (International staff mobility) and https://www.workindenmark.dk

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