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Denmark, PhD Studies in Cutaneous Drug Delivery System – Pharmacology, UCPH

University of Copenhagen (UCPH)

Denmark

Department of Pharmacy, Faculty of Health and Medical Sciences (SUND), University of Copenhagen (UCPH) invites PhD fellowship “Pushing the boundary of cutaneous absorption through supersaturation, penetration enhancement and lipidification” – Denmark, Oct 2021.

 

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General Info

Position: PhD
No. of Positions: 1
Research Field: ,
Deadline to Apply: Expired
Joining Date: Dec 01, 2021 or ASAP
Contract Period: 3 Years
Salary: According to Standard Norms

Workplace:
Faculty of Health and Medical Sciences
Department of Pharmacy
University of Copenhagen (UCPH)
Copenhagen K,

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Qualification Details

We are looking for a highly motivated and enthusiastic individual with the following competencies and experience:

Required qualifications

As an applicant you must have:

  • Obtained a relevant Master´s degree prior to the starting date
  • Fluency in English and excellent communication skills, both oral and written.
  • The ability to work in an interdisciplinary environment.
  • The ability to travel for performing experiments at collaborators.

Preferred qualifications

The ideal candidate for this project has extensive hands-on experience with cutaneous drug delivery systems, including their formulation and characterization using a variety of analytical techniques. Experience with skin permeation experiments is an advantage.

Key criteria for the assessment of applicants

  • Professional qualifications relevant to the PhD programme
  • Relevant work experience
  • Previous publications
  • The grade point average achieved
  • Other professional activities and achievements
  • Language skills

Responsibilities/Job Description

Your key tasks as a PhD fellow at the Faculty are to:

  • Carry through an independent research project under supervision
  • Write scientific manuscripts and the PhD thesis on the grounds of your research project
  • Complete PhD courses or other equivalent education corresponding to approx. 30 ECTS points
  • Obtain experience with teaching and other types of dissemination related to your PhD project
  • Participate in all Center activities
  • Participate in the undergraduate teaching of students in pharmaceutical sciences
  • Participate in national and international conferences and scientific meetings
  • Stay at an external research institution, preferably abroad

How to Apply?

Online Application through "Apply Now" Button from this page or from advertisement webpage (URL below)

Reference Number: -
(If any, use it in the necessary place)

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Documents Required

Your application must include following documents/attachments – all in PDF format:

  • Cover letter (approx. 1 page) describing your background, qualifications, interest and motivation for applying for this position
  • Full CV
  • Diploma and transcripts of records: Master’s degree diploma (including grade transcripts for bachelor´s and master´s degrees). Applicants with a Master´s degree from abroad should also enclose a short description of the grading scale used.
  • Other information for consideration, e.g. list of publications and relevant certificates
  • Names and contact details of references and/or recommendation letters

About the Department

The Department of Pharmacy is offering a three-year PhD fellowship aiming at developing lipid-‑based (trans-)cutaneous drug delivery systems, pushing the free drug concentration in the delivery vehicles to maximal values by increasing the drug load through supersaturation, lipidification and combining such supersaturated systems with terpene-based penetration enhancers. The PhD project will be carried out within the recently established LEO Foundation Center for Cutaneous Drug Delivery (LFCCDD), which integrates several disciplines, including molecular biology, immunology, microbiology, physical chemistry, and pharmaceutics, to perform state-of-the-art research and to create innovative solutions within cutaneous drug delivery of both small and large molecules.

The successful applicant will be a member of the Novel Drug Delivery Systems and Solid state pharmaceutics groups and will have the opportunity for cross-disciplinary research in collaboration with the other sections of the Center as well as external collaborators.

Project description

Despite the numerous advantages of dermal and transdermal drug delivery, compared to other forms of drug administration, this route of delivery continues to be restricted to a comparatively small number of drugs, such as those with a high lipophilicity, a low molecular weight and a low dose. This project attempts to systematically develop cutaneous drug delivery systems for a wider range of drugs. Drugs will be prepared in lipid-based formulations containing the drug in supersaturated and extremely supersaturated forms for both, long-term and short-term stability. This will be combined with the use of chemical penetration enhancers (terpenes with a wide variety of physicochemical properties) and the use of lipidified drugs by lipid salt formation to further increase drug permeation and solubility in the delivery systems and, thus, further enhance the possibilities of supersaturation. Comparison of the use of chemical and physicochemical principles with microneedles at each step of the formulation development will allow the quantitative evaluation of the usefulness of each of the approaches taken. More in detail, the PhD student will work on the characterization, optimization, and performance testing of such systems to finally obtain formulations, which (a) contain drug in maximally supersaturated concentration within the lipid-based drug delivery system, (b) contain the drug in concentrations that allow maximal supersaturation within the delivery system through activation immediately before use, (c) further increase drug concentrations by modifying the drugs through lipidification and create supersaturated states within the delivery system of such modified drugs. All systems will be prepared with and without penetration enhancers for comparison.

About the Employer: University of Copenhagen (UCPH)

Note or Other details

For more information on working and living in Denmark visit http://ism.ku.dk (International staff mobility) and https://www.workindenmark.dk

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Contact details

Principal supervisor: Professor Thomas RadesE-mail: thomas.rades@sund.ku.dk

Co-supervisor: Associate Professor Andrea HeinzE-mail: andrea.heinz@sund.ku.dk

For further information, applicants may contact supervisor Thomas Rades (thomas.rades@sund.ku.dk) or PhD administrator Marianne W. Jørgensen (marianne.joergensen@sund.ku.dk, phone: +45 35 33 64 49).

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