The lab of Neuroepigenetics at the Brain Research Institute of the University and the Institute for Neuroscience of the ETH Zürich, Switzerland is looking for an experienced epigeneticist interested in chromatin remodeling.
The project aims at investigating the mechanisms underlying the impact of life experiences on the genome and epigenome in relation to brain functions and behavior across generations. The purpose is to examine the effects of exposure on genome sequence, structure, and activity including retrotransposition and chromatin looping, and their inheritance in the germline and brain cells.
You will be involved in a project investigating the molecular mechanisms of the expression and inheritance of complex traits resulting from early life experiences in mammals. The project focuses on factors and mechanisms that modify the activity of the genome and chromatin in relation to higher-order brain functions and behavior across generations in mice. The main goals are to identify the processes that link early experiences, particularly traumatic stress, to the regulatory genome and to chromatin structure and functions in the brain and germ cells and assess their causal implication in induced phenotypes.
The candidate will join a pluridisciplinary team at the interface between epigenetics, neuroscience, reproductive biology and bioinformatics using approaches based on environmentally- and genetically-modified mouse models. A close collaboration with team members working on the epigenome and chromatin in germ cells is expected.
Required technical expertise and skills:
- Background in genetics/epigenetics (MSc or PhD)
- Strong technical experience in wet-lab techniques, molecular cloning, cell culture, and associated methods including transfection and viral transduction, flow cytometry, and quantitative microscopy
- Experience in advanced genome/epigenome technologies and multi-omic methods such as RNA-seq, ChIP-seq, and ATAC-seq including library design and preparation
- Experience in the use of CRISPR systems for genome/epigenome editing
- Skills in bioinformatics and data analyses (a plus)
Other skills and experiences:
- Ability to work independently, plan and execute complex experiments and interpret results
- High experimental rigour and precision, strong scientific integrity
- Be proactive in protocols development, be able to recognize technical issues and troubleshoot, and be solution-driven
- Be proficient in recording, tracking, and presenting experimental results accurately
- Highly motivated, flexibility and,ability to learn new skills
- Strong team spirit, willingness to share and help
- Good communication skills
The University and ETH Zürich offer optimal working conditions, ample lab space and technical support, and a rich scientific environment with a large and active community.
This 3-5 years position is available in summer 2023 or anytime later and is in the lab of Prof I. Mansuy, Laboratory of Neuroepigenetics University/ETH Zürich, Irchel Campus, Zürich, Switzerland.
We value diversity
In line with our values, ETH Zurich encourages an inclusive culture. We promote equality of opportunity, value diversity and nurture a working and learning environment in which the rights and dignity of all our staff and students are respected. Visit our Equal Opportunities and Diversity website to find out how we ensure a fair and open environment that allows everyone to grow and flourish.
Curious? So are we.
We look forward to receiving your online application with the following documents:
- Curriculum Vitae including educational history, detailed description of research experience and technical track record
- Motivation letter
- Name and contact details of 2 referees
Please note that we exclusively accept applications submitted through our online application portal. Applications via email or postal services will not be considered. Further information about the Laboratory of Neuroepigenetics can be found on our website.
Questions regarding the position should be directed to Prof. I. Mansuy, email: firstname.lastname@example.org (no applications).
For recruitment services the GTC of ETH Zurich apply.