Postdoctoral Position at EPFL : Optofluidic NanoBiosensors for Cancer Research

EPFL, the Swiss Federal Institute of Technology in Lausanne, is one of the most dynamic university campuses in Europe and ranks among the top 20 universities worldwide. The EPFL employs more than 6,000 people supporting the three main missions of the institutions: education, research and innovation. The EPFL campus offers an exceptional working environment at the heart of a community of more than 16,000 people, including over 12,000 students and 4,000 researchers from more than 120 different countries.Postdoctoral Position at EPFL : Optofluidic NanoBiosensors for Cancer Research

Your mission :The BIOnanophotonic Systems (BIOS) Laboratory at the Institute of Bioengineering of EPFL Switzerland (led by Prof. Hatice Altug) has an open postdoctoral student position to collaborate in a Swiss National Science Foundation Sinergia project with the University of Lausanne (Department of Immunobiology) and the Lausanne University Hospital (Head and Neck Surgery Division and AGORA Cancer Research Center).We are looking for a talented & motivated postdoctoral student to work on the development of cutting-edge nanobiosensors and bioimaging systems for cancer research from understanding of lymph node metastases biology to personalized treatment strategies. Strategies will include engineering nanophotonic substrates for improved sensing performance, setting up multifunctional optical microscopy and spectroscopy systems, building point-of-care optical biosensors, on-chip integration of microfluidic parts for biomolecule detection and cell/organoid analysis, establishing microarray technologies for high throughput screening experiments, handling/characterization of biological samples, optimization of surface functionalization protocols for operation in complex biological matrix, using advanced image/data analysis and demonstration of newly developed platforms for diagnostic applications.

Main duties and responsibilities include : Some of the main tasks include :

  • preparing a research plan
  • nano/microfabrication of optimized device components (nanophotonic chips & microfluidics)
  • reconfiguring optical set-ups
  • optimizing bioassays
  • characterizing/handling biological samples
  • performing optical/biological experiments
  • analyzing optical/biological data
  • reporting and disseminating research outcome

Your profile :Candidate profile:The successful candidate is expected to hold a PhD degree in Bioengineering, Electrical Engineering, Material Science, Biophysics, Biophotonics or a closely related discipline with outstanding academic record indicated by publications in peer-reviewed scientific journals and international conferences. In addition, the following qualifications are desired:

  • Extensive hands-on experimental experience with biosensors (not limited to optical)
  • Hands-on experimental experience in optical microscopy, spectroscopy and optical/electronic instrumentation & performing optical characterization
  • Hands-on experience with microfluidics, BioMEMS, micro-total analysis systems and design principles (fluid analysis) for biomedical and clinical applications
  • Experience in surface functionalization chemistry and bioassay development
  • Experience with biological sample handling and characterization (e.g. cells, organoids, biomolecules)
  • Experience in cleanroom and micro/nanofabrication techniques
  • Experience in programming user interfaces for devices/instrumentation, set-up automation, data extraction (e.g., Python, Matlab, LabVIEW)
  • Experience in data analysis using signal processing tools (also AI, DNN)
  • Fluent in English (both written and spoken) and excellent communication and interpersonal skills
  • Independent, self-driven, creative, solution-oriented, open-minded, flexible and team-player
  • Ability to collaborate with a wide range of interdisciplinary partners (e.g. engineers, physicists, biologists, medical doctors)
  • Well-organized, eager to learn, and able to take responsibility and define priorities quickly

We offer :We offer:

  • Opportunity to work on multidisciplinary and cutting-edge projects using nanophotonics,  spectroscopy and lab-on-a-chip systems for bioanalytical and biomedical applications
  • Opportunity to access state-of-the-art research facilities and laboratory resources
  • Opportunity to collaborate with world-leading cancer research groups and medical doctors through a multidisciplinary consortium funded by Swiss National Science Foundation Sinergia grant
  • EPFL is an international and top ranking engineering university. It offers a young, stimulating, dynamic, interdisciplinary, international and friendly working environment, a broad range of scientific training and networking events and hosts a vibrant entrepreneurial community
  • EPFL is an equal-opportunity employer. Candidates will be recruited based on merit

Keywords:Nanophotonics, optical nanobiosensors and bioimaging systems, lab-on-a-chip systems, microarrays, microTAS, biological samples, diagnostics, cancer research

Group website: https://www.epfl.ch/labs/bios/ – Group leader: Prof. Hatice ALTUG

Representative papers from BIOS:

  1. Real-time monitoring of single-cell secretion with a high-throughput nanoplasmonic microarray. Liu et al. Biosensors and Bioelectronics, 113955 (2022)
  2. Imaging-based spectrometer-less optofluidic biosensors based on dielectric metasurfaces for detecting extracellular vesicles. Jahani et al. Nature Communications. Vol. 12, No.3246 (2021)
  3. Rapid and Digital Detection of Inflammatory Biomarkers Enabled by a Novel Portable Nanoplasmonic. Imager. Belushkin et al. Small. Vol. 16, No.1906108 (2020)

Relevant review paper: Advances and Applications of Nanohotonic Biosensors. Altug et al. Nature Nanotechnology. Vol. 17, p.5-16 (2022)

Start date :As soon as possible
Term of employment :Fixed-term (CDD)
Work rate :100%
Duration :Fixed term (2 years, renewable)

Contact :Please send your application with the subject line « 2023 Postdoctoral Position» to bios@epfl.ch in a single pdf file containing following information: cover letter, CV, transcript, list of publications, and contact details of at least three referees.

Reference :Job Nb 2742