1-2 Postdoctoral studies in characterization of the immuno-oxylipidome in atherosclerosis

Cardiovascular disease (CVD) is, the leading cause of mortality and a major cause of morbidity in Europe, affecting the lives of over 49 million people and costing €200 billion to the EU economy. The dysregulated chronic inflammation behind atherosclerotic CVD and its cardiovascular consequences are largely caused by a failure in the resolution of inflammation. The Unit of Integrative Metabolomics and the Translational Cardiology group and are seeking 1-2 postdoctoral fellows to work in the framework of the recently funded HORIZON project “CARE-IN-HEALTH (2023-2027). The ambition of the CARE-IN-HEALTH project is to take the chronic inflammation concept to the next level: Resolution-health. The project goal is to enable a paradigm shift in staying healthy via promotion of the resolution of inflammation. The main aim is to identify the resolution of the chronic lipid-driven/-regulated vascular inflammation. These efforts will include developing and testing tools for use in health care to maintain health through resolution of the chronic inflammation driving the health-to-cardiovascular disease (CVD) transition. The project will employ mass spectrometry to analyze samples from observational cohorts and clinical trials to create a comprehensive oxylipidomic map of the inflammatory component in the health-to-CVD transition. This information will be used to distinguish between resolving and non-resolving inflammation and to identify signature lipid markers to be applied for early detection, diagnosis, risk stratification and prevention of CVD.

Your mission

We have an opening for 1-2 postdoctoral scholarships to this translational and multidisciplinary research team with the overarching aim to understand the role of oxylipin lipid mediators in the health-to-disease transition. Focus will be placed upon oxylipins produced from polyunsaturated fatty acids, including octadecanoids, eicosanoids, and docosanoids in atherosclerotic cardiovascular disease. The research scope will include applying existing mass spectrometry-based methods as well as developing new protocols to quantify specialized pro-resolving lipid mediators (SPMs) and related molecules. Analyses will involve applying these methods in both clinical samples and experimental models to map the biochemical role of oxylipins in health and disease. These data will be used in the overall project aim to draw a personalized blueprint of chronic inflammation in the health-to-disease transition, map the lipid immune landscape, and understand the role of lipids in maintaining an individual’s cardiovascular health.

Qualifications

We are looking for motivated candidates with a Ph.D. in mass spectrometry or bioanalytical chemistry. The successful candidate will be expected to use and further develop mass spectrometry-based methods. Accordingly, applicants must document their experience in small molecule mass spectrometry by LC-MS/MS. Previous experience working with bioactive lipid mediators in inflammatory systems is considered a merit. Excellent communication skills and an ability to interact socially and scientifically with other members of the laboratory and with collaborators in various networks are essential.

Entry requirements

Scholarships for postdoctoral qualification can be established for foreign researchers who place their qualifications in Sweden. The purpose of scholarships for postdoctoral qualification is to promote internationalization and contribute to research qualification after a doctorate or equivalent.A scholarship for carrying out postdoctoral research can be granted for a maximum of two years within a four year period following the receipt of a doctoral degree or equivalent.To be eligible for a postdoctoral scholarship, the person must have obtained a doctorate or a foreign degree deemed to be equivalent to a doctorate. Applicants who have not completed a doctorate at the end of the application period may also apply, provided that all requirements for a completed degree are met before the (intended) start date of the post doctoral education.

The head of the department determines whether their previous training and scholarly qualifications correspond to a Swedish doctorate or higher.

Location: Solna

Type of scholarship

The amount is tax free and it is set for twelve months at a time, paid out on a six months basis. In exceptional cases, shorter periods may be acceptable.

Application process

An application must contain the following documents in English or Swedish:

  • A complete curriculum vitae, including date of the thesis defence, title of the thesis, previous academic positions, academic title, current position, academic distinctions, and committee work
  • A complete list of publications
  • A summary of current work (no more than one page)

The application is to be submitted on the Varbi recruitment system.

Contact

  • Craig Wheelock, Principal researcher, craig.wheelock@ki.se

Union representative

  • Anne Boström, SEKO , 08-52487579,anne.bostrom@ki.se
  • Niklas Andersson, OFR , 08-52487419,niklas.andersson@ki.se
  • Anda Gliga Saco-S, anda.gliga@ki.se