Ref PAR 2023/660
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Doctoral position in Medical Science
Project title: Genomic study of clonal hematopoiesis
The Department of Medical Biochemistry and Cell biology, is located at the Institute of Biomedicine at the Faculty of Medicine at Sahlgrenska Academy, University of Gothenburg.
General information about being a doctoral student at the University of Gothenburg can be found on the university’s doctoral student pages https://medarbetarportalen.gu.se/doktorand/?languageId=100001&skipSSOCheck=true
The PhD education in Medical Science comprises carrying out a scientific project and completing at least 30 credits of courses at third-cycle level. The doctoral student must also write a scientific compilation thesis or monograph corresponding to at least 120 credits. For more information about third-cycle studies at Sahlgrenska Academy, see https://www.gu.se/en/sahlgrenska-akademin/doctoral-studies
Project: Clonal hematopoiesis (CH) is an early stage of blood cancer development, where a large fraction of blood cells originates from a single hematopoietic stem cell lineage. CH can be detected in DNA sequencing data from blood cells of healthy individuals based on somatic genetic variants. CH carries an increased risk of leukemia and age-related diseases. Recently, we distinguished two groups of clonal hematopoiesis and stratified risk of developing distinct types of blood cancers (Niroula et al., Nature Medicine 2021). In this PhD project, we aim to identify new genetic variants underlying CH and identify regulators of CH development. The findings will be used for predicting the risk of developing blood cancer. This data-driven project will involve large-scale analysis of next-generation sequencing (NGS) data. As a PhD student, you will develop computational workflows to analyze NGS data. You will work in an interdisciplinary data-driven life science (DDLS) research team. You will be affiliated to the national DDLS program.
Education at third-cycle level comprises four years of full-time study, and leads to a doctoral degree. As part of your employment as a doctoral student, you may have departmental duties corresponding to up to 20 % of full-time employment, distributed throughout your study period. Departmental duties usually consist of teaching at first- and second-cycle levels, but may also include research and administration.
Education at third-cycle level requires general eligibility and specific eligibility as set out in the general syllabus for the subject.
The general eligibility requirements for education at third-cycle level are: 1. having completed a degree at second-cycle level, or2. the fulfilment of course requirements totalling at least 240 credits, of which at least 60 credits must be at second-cycle level, or 3. the acquisition of equivalent knowledge in some other way, either in Sweden or abroad. Specific entry requirements for this subject, according to the general syllabus, are: having completed the English B/6 course or is considered to have acquired equivalent knowledge through previous studies.
The selection of applicants who are considered to have the ability required to benefit from the study programme and who meet the general and specific eligibility requirements are assessed based on the following documented qualifications:- specific knowledge and skills within the subject area and related research fields- experience of scientific theory and relevant research methodology- scientific analysis and presentation verified through thesis, degree project, scientific journals or the like.
Documented experience of programming (R and python) and working in Linux environment are advantageous.
Once you have been admitted for education at third-cycle level, you will be employed as a doctoral student at the University of Gothenburg. The provisions for employment as a doctoral student can be found in ordinance SFS 1993:100. Initial employment as a doctoral student may apply for a maximum of one year, and may be renewed by a maximum of two years at a time. A doctoral student may be employed as a doctoral student for a maximum of eight years, but the total period of employment may not be longer than the equivalent of full-time education at third-cycle level for four years.
Location: Sahlgrenska Academy, Institute of Biomedicine, Department of Medical Biochemistry and Cell biology. Extent: 100%. First day of employment: as agreed.
The University applies a local agreement on salaries for doctoral students.
For more information about the project please contact the principal supervisor,Abhisek Niroula, Associate Senior Lecturer, Institute of Biomedicine,e-mail:firstname.lastname@example.org
Union representatives at the University of Gothenburg can be found here: https://www.gu.se/om-universitetet/jobba-hos-oss/hjalp-for-sokande
You can apply to be admitted for education at third-cycle level via the University of Gothenburg’s recruitment portal. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline.
You must include the following, in pdf format
- Personal letter
- Diploma and transcripts showing that you meet with the general entry requirement
- Proof of completion of English 6 course or the acquired equivalent knowledge through previous studies
If your degree is from a university outside of Sweden, make sure that you attach a diploma and full transcripts that makes assessing your degree easier.
If your degree has not been verified by a Swedish authority you need to provide contact details to the issuing university, registrar or similar, that can verify the degree at our request.
For information on what you need to submit in order to fulfill the English language requirement see https://www.universityadmissions.se/en/entry-requirements/english-language-requirements/
Applications must be received by: 2023-06-15
Information for International Applicants
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The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations.
Salaries are set individually at the University.
In accordance with the National Archives of Sweden’s regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed.
In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.