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2 PhD Positions – CAR T-Cells Study, Biomedical Science, Pharmaceutical Engineering

Technical University of Denmark (DTU)

Denmark

Technical University of Denmark (DTU) invites applications for 2 PhD Positions in Building novel molecular circuits to enhance the secretory properties of CAR T-cells at Center for Nano-Immune Cell-Engineering (NICE), DTU Health Tech, Denmark – Oct 2021 (Opportunities for Immunology, Nanotechnology, Biomedical Science, Pharmaceutical Engineering degree holders)

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General Info

Position: PhD Positions
No. of Positions: 2
Research Field: , , ,
Deadline to Apply: Expired
Joining Date: ASAP
Contract Period: 3 Years
Salary: According to Standard Norms

Workplace:
Center for Nano-Immune Cell-Engineering (NICE)
DTU Lyngby Campus, DTU Health Tech
Technical University of Denmark (DTU)
Lyngby,

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Qualification Details

  • The candidate must hold a two-year master's degree (120 ECTS points) ideally in immunology, biomedical science, pharmaceutical engineering, nanotechnology or related disciplines.
  • The candidate should have solid skills in T-cell culture techniques, viral and non-viral transduction methods, and flow cytometry.
  • Experience with CAR T cell design and testing is considered an advantage but not a requirement.
  • Expertise in neuroimmunology is considered an advantage but not a requirement
  • The candidate should demonstrate evidence of self-driven and independent research capability, good problem-solving skills, excellent writing and communication skills, an interest in working in an interdisciplinary environment, and a strong motivation to succeed within the competitive research field.

Responsibilities/Job Description

Project 1

The candidate will be responsible for establishing in vitro assays to test targeted delivery of the CAR gene to T cells. The main tasks include:

  • Design molecular circuits which can enhance the secretory properties of payloads from CAR T-cells;
  • Establish in vitro and in vivo systems to evaluate specific secretion of payloads from CAR T-cells:
  • Optimize current gene delivery tools to improve transduction efficacy;
  • Disseminate and communicate the results through journal and conference publications.

Project 2:

The candidate will be responsible for evaluation the immune repertoire and T cell infiltration to CNS, with the purpose of facilitation immunotherapy strategies targeting CNS disease:

  • Determine the composition of immune cells in CSF during CNS disease
  • Establish in vitro and in vivo systems to evaluate immune interactions of relevance for CNS entry or CNS disease
  • Improve T cell targeting to Glioma and identify optimal targeting and homing molecules.
  • Disseminate and communicate the results through journal and conference publications.

How to Apply?

Online Application through "Apply Now" Button from this page`

Reference Number: -
(If any, use it in the necessary place)

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Documents Required

Please submit your online application no later than Tuesday, 12 October 2021 (Danish time). Applications must be submitted as one pdf file containing all materials to be given consideration. To apply, please open the link "Apply online," fill in the online application form, and attach all your materials in EnglishThe file must include: 

  • Cover letter stating your specific interest, motivation and qualifications for the project.
  • Curriculum vitae including relevant information on previous employment, research training, experience and competencies, teaching experience, list of scientific publications, conference presentations and personal references.
  • Diploma: Authorized copies of BSc and MSc diplomas, and transcript of grades (an official translation into English)
  • Excel sheet with translation of grades to the Danish grading system (see guidelines and Excel spreadsheet here)

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

The applicants will be assessed by Prof. Sine Reker Hadrup and postdoc Maria Ormhøj. Potential candidates will be contacted for interview.

About the Project

NICE is a newly established center funded by Novo Nordisk Fonden’s Challenge Programme 2021. The overall aim of NICE is to change the way we treat cancer today by solving the challenges associated with CAR T-cell therapy. The successful candidate will join our interdisciplinary team comprising of excellent material scientists, immunologists and molecular biologists.

About the Employer: Technical University of Denmark (DTU)

Offer

We offer an exciting and challenging job in an international environment focusing on education, research and innovation. There are good possibilities for both professional and personal growth. We offer a great flexibility in the position. In the area of technical and natural sciences, DTU is one of the leading research and education institutions in Europe.

Salary and appointment terms

The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union according to your experience and seniority. The period of the contract is 3 years.The position will be based at the DTU Lyngby Campus, Denmark, and will start as soon as possible.You can read more about career paths at DTU here

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Contact details

Further information may be obtained from Professor Sine Reker Hadrup (sirha@dtu.dk) and postdoc Maria Ormhøj (marorm@dtu.dk).

You can read more about DTU Health Tech at www.healthtech.dtu.dk/english.  

If you are applying from abroad, you may find useful information on working in Denmark and at DTU at DTU – Moving to Denmark.   

Advertisement Details: PhD Positions (2) in Building Novel Molecular Circuits to Enhance the Secretory Properties of CAR T-Cells

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