PhD position on molecular mechanisms of drug resistance in breast cancer using genetic screens and 3D tissue-engineered constructs

A PhD position is available in the laboratory of Professor Momo Bentires-Alj (https://bentireslab.org/) at the Department of Biomedicine (DBM) in Basel, Switzerland. The successful candidate will study molecular mechanisms of resistance to breast cancer therapy using bioengineered ex vivo cultures of patient breast tissues, clonal barcoding, CRISPR-Cas9 libraries, mouse models, and image-based drug screening (Pharmacoscopy).Selected publications of our lab include: 1- PIK3CAH1047R induces multipotency and multi-lineage mammary tumors. Koren S, et al., Nature 2015. 2- Hippo kinases LATS1/2 control human breast cell fate via crosstalk with ERα. Britschgi A, et al., Nature 2017. 3. Glucocorticoids promote breast cancer metastasis. Obradović MMS, et al. Nature 2019. 4. Hepatic stellate cells suppress NK cell sustained breast cancer dormancy. Correia AL, et al., Nature 2021.

Your position The tasks include:

  • Manage and characterize breast cancer patient-derived organoid samples
  • Assess their response to single or combination therapy using image-based drug screening (Pharmacoscopy)
  • Validate the findings in vivo

Your profile A strong experience in primary cell culture, 3D cultures and tissue engineering, molecular cloning, and imaging. Expertise in drug screening, and/or mouse work is a plus. The candidate should be well organized, highly motivated, a team player, and must be fluent in English.

We offer you A stimulating, challenging and interdisciplinary translational research environment, state-of-the-art technologies and core facilities, and attractive employment conditions. The DBM is an international institute pursuing basic, translational and clinical research, with access to cutting-edge core facilities. Lab website: https://bentireslab.org/.

Application / Contact Please upload your CV, a summary of your research experience and interests, techniques that you are competent in, and the contact details of three referees at:https://biped2.dbm.unibas.ch/apply/phd-application-bentires-lab

Application deadline: applications will be reviewed as they arrive.